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Role of human Cytomegalovirus in the etiology of nasopharyngeal carcinoma


1 Molecular Diagnostics and Personalized Therapeutics Unit, University of Hail; Department of Pathology, College of Medicine, University of Hail, Hail; Department of Histopathology and Cytology, FMLS, University of Khartoum, Kingdom of Saudi Arabia
2 Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, University for Science and Technology, Khartoum, Sudan
3 Molecular Diagnostics and Personalized Therapeutics Unit, University of Hail; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Kingdom of Saudi Arabia
4 Department of Pathology, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia
5 Department of Anatomy and Histology, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia

Correspondence Address:
Hussain Gadelkarim Ahmed,
Department of Pathology, College of Medicine, University of Hail, Hail 2440
Kingdom of Saudi Arabia
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Source of Support: None, Conflict of Interest: None

Objective: The purpose of this study was to identify human Cytomegalovirus (HCMV) in tissue blocks obtained from patients with nasopharyngeal carcinoma (NPC). Materials and Methods: Formalin-fixed paraffin wax processed NPC tissue were obtained from 150 tissue blocks and retrospectively investigated for the presence of HCMV using polymerase chain reaction. Results: Of the 150 NPC tissue specimens, HCMV was identified in 53/150 (35.3%) of the samples. Out of the 53 samples infected with HCMV, 33/97 (34%) were among males and 20/53 (37.7%) were among females. Of the 53 positive samples, 36/53 (68%) were found to harbor Epstein–Barr virus (EBV). Conclusion: The present study has shown a relatively considerable association between HCMV and NPC. The great majority of samples sheltering HCMV were also found to hide EBV, which proposes the potentiality of EBV over HCMV.


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    -  Suliman RS
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