Nueclear Web Banner
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
 
ORIGINAL ARTICLE
Ahead of Print

Promoter methylation of human mutL homolog 1 and colorectal cancer risk: A meta-analysis


1 Combine Traditional Chinese and Western Medicine of Oncology, Henan Tumor Hospital, Henan, China
2 Department of Oncology, Henan Tumor Hospital, Zhengzhou 450008, Henan, China

Correspondence Address:
Qilong Gao,
No. 127 Dongming Road, Zhengzhou 450008, Henan
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Aims: Several studies suggested that promoter methylation of human mutL homolog 1 (hMLH1) was associated with the risk of colorectal cancer (CRC). However, other studies did not indicate the same results. To derive a more comprehensive estimation of the association between hMLH1 methylation and CRC risk, we conducted a meta-analysis. Materials and Methods: We searched in the PubMed, EMBASE, and WanFang Medicine databases. The strength of the associations was measured by odds ratios (ORs) with 95% confidence intervals (CIs). Results: A total of 47 studies with 4296 cases and 2827 controls were included. A statistically significant association between hMLH1 methylation and CRC risk was found (OR = 9.25; 95% CI, 5.65-15.53; P < 0.001). The heterogeneity was significant (P < 0.001). In the subgroup analysis of race, Asian and Caucasian with hMLH1 methylation had increased CRC risk (OR = 12.19; 95% CI, 7.02-23.42; P < 0.001 and OR = 6.38; 95% CI, 2.17-19.64; P < 0.001). In the subgroup analysis of sample source, only the sample from tissue showed increased CRC risk (OR = 10.46; 95% CI, 6.12-17.90; P < 0.001). The Egger's test did not find publication bias (P = 0.176). Conclusions: In conclusion, this meta-analysis suggested that hMLH1 methylation was associated with an increased CRC risk.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Shi B
    -  Chu J
    -  Gao Q
    -  Tian T
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed292    
    PDF Downloaded19    

Recommend this journal