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Peroxisome proliferators-activated receptor gamma polymorphisms and colorectal cancer risk


1 Colorectal Disease of Guangdong Provincial Hospital of Chinese Medicine; The 2nd Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510120, China
2 The 2nd Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510120, China

Correspondence Address:
Xuemin Liang,
Guangzhou Dade Road No. 111, Guangzhou 510120
China
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Source of Support: None, Conflict of Interest: None

Aims: Several studies evaluated the association between peroxisome proliferators-activated receptor gamma (PPARg) Pro12Ala (rs1801282), and His477His (rs3856806) polymorphisms and the risk of colorectal cancer (CRC). However, the results were not stable. Materials and Methods: We searched databases containing PubMed and EMBASE. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. Results: A significantly decreased CRC risk was found for PPARg Pro12Ala polymorphism (OR = 0.88, 95% CI 0.83-0.94, P < 0.0001). In the subgroup analysis by race, a significantly decreased risk was found in the Caucasian population (OR = 0.89, 95% CI 0.83-0.95, P = 0.0003) but not in Asian population (OR = 0.76, 95% CI 0.57-1.02, P = 0.07). In the subgroup analysis by CRC location, significantly decreased risks were found in rectal cancer (OR = 0.88, 95% CI 0.77-1.00, P = 0.05) and colon cancer (OR = 0.82, 95% CI 0.73-0.92, P = 0.0008). In addition, a significantly decreased CRC risk was also detected for PPARg His477His polymorphism (OR = 0.66, 95% CI 0.44-1.00, P = 0.05). In the subgroup analysis by race, a significantly decreased risk was found in the Caucasian population (OR = 0.43, 95% CI 0.26-0.69, P = 0.0006) but not in Asian population (OR = 0.95, 95% CI 0.73-1.25, P = 0.72). Conclusions: PPARg Pro12Ala and His477His polymorphisms might be associated with susceptibility of CRC.


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