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miR-146a rs2910164 polymorphism and the risk of colorectal cancer in Chinese population


1 Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu 210009, China
2 Department of Pathology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, China
3 Department of General Surgery, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, China

Correspondence Address:
Zhansheng Zhu,
Department of Pathology, Xuzhou Medical College, Xuzhou, Jiangsu 221004
China
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Source of Support: None, Conflict of Interest: None

Objective : MicroRNAs-associated single nucleotide polymorphisms are thought to play an important role in cancer development. We investigated the association of miR-146a rs2910164 polymorphism with the risk of colorectal cancer (CRC) in Chinese population. Materials and Methods: In this hospital-based case-control study of 560 cases and 780 age- and gender-matched healthy controls, the miR-146a rs2910164 polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism. Results: We found that miR-146a rs2910164 polymorphism was not associated with CRC risk. However, the subgroup analysis by gender showed significant associations in male subjects (GG vs. CC: Odds ratios [OR] = 1.54, 95% confidence intervals [CI] = 1.04-2.29, P = 0.03; G vs. C: OR = 1.21, 95% CI = 1.01-1.45, P = 0.04). Conclusion: Our study provides evidence that miR-146a rs2910164 polymorphism may play an important role in susceptibility to CRC in Chinese male population.


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