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Circulating gelatinases are not prognostic of treatment response and survival in locally advanced rectal cancer patients undergoing preoperative chemoradiotherapy


1 Department of Radiation Oncology, Gazi University Hospital, Ankara, Turkey
2 Department of Radiation Oncology, Kartal Training and Research Hospital, Istanbul, Turkey
3 Department of Biochemistry, Gazi University Hospital, Ankara, Turkey

Correspondence Address:
Sukran Ulger,
Department of Radiation Oncology, Gazi University Hospital, 06500 Besevler, Ankara
Turkey
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Source of Support: None, Conflict of Interest: None

Purpose: To investigate whether the serum levels of matrix metalloproteinases (MMPs) are predictive on treatment response and survival in locally advanced rectal cancer (LARC) patients undergoing preoperative chemoradiotherapy. Patients and Methods: Serum MMP-2 and MMP-9 was analyzed by enzyme-linked immunosorbent assay and obtained before, midway, and 1-month after the end of preoperative radiotherapy treatment. The prognostic significance of serum MMP-2 and MMP-9 levels and their association with other pathological findings for LARC patients were evaluated. Results: Serum levels of MMP-2 or MMP-9 were found to decrease with increasing clinical stage and negative correlation was statistically significant (P < 0.05). There was no statistically significant difference in tumor response and survival between the low and high MMP-2 and MMP-9 groups. MMP-2 and MMP-9 were not correlated with local-regional recurrence. Conclusions: We propose that serum levels of MMP-2 and MMP-9 are not predictive on treatment response and survival in LARC patients.


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    -  Ulger S
    -  Kilic D
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