Nueclear Web Banner
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 

Ahead of print publication  

Sentinel lymph node status affects long-term survival in patients with intermediate-thickness melanoma

1 Department of Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey
2 Department of Surgery, Bayindir Hospital Kavaklidere, Ankara, Turkey
3 Department of Surgery, Samsun Training and Research Hospital, Samsun, Turkey

Correspondence Address:
Kaptan Gülben,
Department of Surgery, Kardelen Mah. 2040. Sok., Bat?park Konutlar?, B/27, 06370 Ankara
Login to access the Email id

Source of Support: None, Conflict of Interest: None

 > Abstract 

Objective: The aim of this study was to examine the role of sentinel lymph node biopsy (SLNB) on long-term disease outcome in patients with intermediate-thickness primary cutaneous melanomas.
Materials and Methods: Forty patients with intermediate-thickness melanomas, defined as 1.0-4.0 mm, underwent SLNB between 1998 and 2011. The disease-free survival (DFS), overall survival (OS) and prognostic factors were analyzed.
Results: Median age was 53 years (range: 24-74 years). Median Breslow thickness was 2.8 mm (range: 1.0-4.0 mm) and 27.5% were ulcerated melanomas. Median follow-up time was 70 months (range: 23-168 months). The number of patients with sentinel lymph node (SLN)-positive was 9 (22.5%) and completion lymph node dissection was performed in all of these patients. Ten patients (25%) developed distant and locoregional recurrence; 4 in the SLN-positive group (4/9; 45%) and 6 in the SLN-negative group (6/31; 19%), P < 0.042. In the SLN-negative group, one patient developed regional node recurrence; false-negative rate was 10%. SLN positivity and ulceration were independent prognostic factors for DFS in multivariate analysis (hazard ratio [HR] of 4.6, and 10.5, respectively; P < 0.011). For OS SLN positivity, ulceration and Breslow thickness were found to be the significant prognostic factors (HR of 5.4, 8.5 and 5.0, respectively; P < 0.024). Ten-year DFS and OS for SLN-negative and SLN-positive patients were 71%, 47% (P < 0.003), and 80%, 55% (P < 0.005), respectively.
Conclusion : This study shows that survival rates are worse in the SLN-positive patients according to the long-term follow-up data. Ulceration and Breslow thickness also have significant effects on long-term survival in patients with intermediate-thickness primary cutaneous melanomas.

Keywords: Follow-up, melanoma, sentinel lymph node, survival

How to cite this URL:
Gülben K, Berberoglu U, Altinyollar H, Kinas V, Turanli S. Sentinel lymph node status affects long-term survival in patients with intermediate-thickness melanoma . J Can Res Ther [Epub ahead of print] [cited 2018 Mar 24]. Available from:



     Search Pubmed for
    -  Gülben K
    -  Berberoglu U
    -  Altinyollar H
    -  Kinas V
    -  Turanli S
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article

 Article Access Statistics
    PDF Downloaded43    

Recommend this journal