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Year : 2020  |  Volume : 16  |  Issue : 1  |  Page : 192-193

Successful management of solitary gastric plasmacytoma in a 22-year-old woman using a new protocol for combination therapy

1 Department of Pathology, AMRI Hospitals, Kolkata, West Bengal, India
2 Department of Oncology, AMRI Hospitals, Kolkata, West Bengal, India
3 Institute of Hematology and Transfusion Medicine, Medical College and Hospital, Kolkata, West Bengal, India

Date of Submission03-Jul-2018
Date of Acceptance06-Dec-2018
Date of Web Publication20-Aug-2019

Correspondence Address:
Subhashis Mitra
Department of Pathology, AMRI Hospitals, Kolkata - 700 029, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcrt.JCRT_434_18

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How to cite this article:
Mitra S, Chakraborty SM, Chatterjee P, Bhattacharyya M. Successful management of solitary gastric plasmacytoma in a 22-year-old woman using a new protocol for combination therapy. J Can Res Ther 2020;16:192-3

How to cite this URL:
Mitra S, Chakraborty SM, Chatterjee P, Bhattacharyya M. Successful management of solitary gastric plasmacytoma in a 22-year-old woman using a new protocol for combination therapy. J Can Res Ther [serial online] 2020 [cited 2020 Jun 6];16:192-3. Available from: http://www.cancerjournal.net/text.asp?2020/16/1/192/257924


Extramedullary plasmacytomas (EMPs) of the gastrointestinal system are rare tumors, with no established consensus on treatment. We present the case of a 22-year-old woman with primary gastric plasmacytoma (GP) who was successfully managed with a three-pronged combination of endoscopic mucosal resection (EMR), radiotherapy, and chemotherapy. The patient presented with fever, epigastric pain, and gradual weight loss for 6 months. Medical history was unremarkable, and routine laboratory investigations were normal, except for anemia (9.0 g/dL). Total serum protein was normal (7.22 g/dL), but albumin/globulin ratio was inverted (0.7). Upper gastrointestinal endoscopy showed chronic friable erosions at lesser curvature of the stomach, and entire ulcerated area was sampled for biopsy.

Histopathology revealed focal mucosal erosions and dense plasma cell infiltration in submucosa with interspersed inflammatory cells. Immunohistochemistry showed plasmacytoid cells positive for CD 138, CD 45, and Kappa light chain; and immunonegative for CD 20, CD 3, CD 5, and lambda light chain. MIB-1 index was 5% [Figure 1].
Figure 1: (a) Section of gastric endoscopic biopsy showing sheets of plasma cells in lamina propria (H and E, ×400). (b) Immunohistochemistry on gastric biopsy section showing membranous positivity of plasmacytoid cells for CD138 (Immunoperoxidase, ×400). (c) Immunohistochemistry on gastric biopsy section showing Kappa light chain positivity in tumor cells (Immunoperoxidase, ×400). (d) Immunohistochemistry on gastric biopsy section showing tumor cells negative for lambda light chains (Immunoperoxidase, ×400)

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Whole-body positron emission tomography (PET) scan showed fluorodeoxyglucose avid focal thickening in gastric corpus, focal colonic hypermetabolism, and diffuse marrow uptake. Bone marrow studies showed erythroid hyperplasia and 2% mature plasma cells. Repeat endoscopy revealed ulcerations in the body of the stomach, normal colon, and solitary rectal ulcer. Active proctitis and plasmacytoid infiltration in ulcerated gastric mucosa were diagnosed on endoscopic biopsy. Serum protein electrophoresis, immunofixation electrophoresis, and free light chain assay revealed serum monoclonal gammopathy, with gamma heavy chain and kappa light chain monoclonal protein. Beta-2-microglobulin level was 2.24 mg/L. Urinary Bence Jones protein was not detectable. A final clinical diagnosis of multiple myeloma with extramedullary GP was made.

Considering the younger age of the patient, localized tumor, no regional lymphadenopathy, and uninvolved bone marrow; EMR was deemed adequate, and further treatment was based on the combination of intravenous bortezomib, oral dexamethasone, and regional radiotherapy localized to the stomach and perigastric lymph nodes. A total dosage of 45 Gy fractionated over 25 doses was administered. Complete treatment schedule was tolerated well by the patient.

Biochemical and bone marrow studies were repeated after 8 and 16 months. There was loss of monoclonal protein, reduction in total immunoglobulin levels, and normal marrow plasma cells; and the patient remains symptom-free till date.

EMPs of the gastrointestinal system are rare plasma cell neoplasms, and GPs account for 2%–5% of all EMPs.[1] Gastrointestinal symptoms are most common presenting feature, and endoscopy can reveal gastric nodules, polyps, mucosal infiltration, or ulcers.[2] Endoscopic findings simulate adenocarcinoma, and sufficient number of biopsies is recommended for accurate diagnosis.[3] Computed tomography, magnetic resonance imaging, and PET scans can aid diagnosis.[4] Differential diagnoses include lymphoplasmacytic and mucosa-associated lymphoid tissue lymphomas, plasma cell granuloma, and Castleman's disease. Predominant population of CD 20 negative and CD 138 positive plasma cells with the absence of centrocytes, follicles, or lymphoepithelial lesions, is typical of EMPs.[5]

Meta-reviews identified <20 cases of primary gastric EMP, predominantly in elderly males. Most cases have mucosal tumors, and there is no established treatment guideline. Endoscopic mucosal/submucosal resection has achieved complete remission in three cases. Systemic chemotherapy with or without radiotherapy or surgery is usual approach.[1],[2],[6] Combination therapy of bortezomib, dexamethasone, and surgery has proven effective in advanced cases.[1] A causal relationship with Helicobacter pylori infection has been postulated.[2],[5],[6]

Despite no long-term follow-up studies of GPs, the prognosis is favorable with a 70% disease-free survival at 10 years. The rate of progression of EMP to multiple myeloma ranges from 11% to 30%, at 10 years.[5] A combination protocol of EMR, local radiotherapy, and bortezomib chemotherapy with dexamethasone, as in this case, can be considered a safe and effective approach in cases of GPs limited to mucosa; with follow-up and endoscopic monitoring as indicated.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that name and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

 > References Top

Fukuhara S, Tazawa H, Okanobu H, Kida M, Kido M, Takafuta T, et al. Successful treatment of primary advanced gastric plasmacytoma using a combination of surgical resection and chemotherapy with bortezomib: A case report. Int J Surg Case Rep 2016;27:133-6.  Back to cited text no. 1
Souto Filho JT, Lemos LV, Vieira Junior MC, Barboza KP, Castelar BM, Ribeiro AE, et al. Long-term complete remission of primary gastric plasmacytoma following endoscopic resection. Ann Hematol 2017;96:1053-6.  Back to cited text no. 2
Han YJ, Park SJ, Park MI, Moon W, Kim SE, Ku KH, et al. Solitary extramedullary plasmacytoma in the gastrointestinal tract: Report of two cases and review of literature. Korean J Gastroenterol 2014;63:316-20.  Back to cited text no. 3
Zhao ZH, Yang JF, Wang JD, Wei JG, Liu F, Wang BY . Imaging findings of primary gastric plasmacytoma: A case report. World J Gastroenterol 2014;20:10202-7.  Back to cited text no. 4
Krishnamoorthy N, Bal MM, Ramadwar M, Deodhar K, Mohandas KM. A rare case of primary gastric plasmacytoma: An unforeseen surprise. J Cancer Res Ther 2010;6:549-51.  Back to cited text no. 5
Zhang D, Cao D, Shen D, Mulmi Shrestha S, Yin Y. Extramedullary plasmacytoma occuring in ileocecum: A case report and literature review. Medicine (Baltimore) 2017;96:e9313.  Back to cited text no. 6


  [Figure 0], [Figure 1]


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