|Year : 2019 | Volume
| Issue : 5 | Page : 1197-1200
Corrected and Republished: Abstracts
|Date of Web Publication||4-Oct-2019|
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
. Corrected and Republished: Abstracts. J Can Res Ther 2019;15:1197-200
Link to Erratum:
These below abstracts from a supplement issue of Journal of Cancer Research and Therapeutics - Supplement 1 - 2017 - Volume 13 are being republished due to multiple errors such as author name correction, missing author names and authors being incorrectly mentioned as “Presenters”.
Abstract Id: YUGP1005
T cell rich B cell Lymphoma of the Breast- A Rare Case Report with emphasis on the role of Immunohistochemistry in the diagnosis
Presenter- *Dr. Sulav Sapkota
Co-author - Naik R
Primary breast lymphoma is a rare tumour that commonly presents as a large lump with an incidence of less than 0.5%. It can be confused with poorly differentiated carcinoma on routine FNAC. T-CELL-RICH B-cell lymphoma (BCL) is a recently described histologic variant of BCL characterized by a minor population of clonal B cells distributed in a back- ground of numerically preponderant polyclonal T lymphocytes.' While precise histologic criteria have not yet been defined, clonal B cells typically comprise 10% or less of the total cellular constituency.
Case History: A Forty one year old female, previously diagnosed and treated for T cell NHL of left breast two years back presented with a 3X4 cm, rubbery, nontender, mobile mass in the upper outer quadrant of left breast. Bilateral Mammography showed multiple ill defined nodular opacities in left axillary tail. Biopsy of the breast lump and lymph node revealed T-cell rich B-cell lymphoma of breast. Immune-histochemistry definitely proved it to be a case of TCRBCL.
Conclusion: Non Hodgkins Lymphoma especially T cell rich B cell Lymphoma involving the breast as a primary site or as a secondary site from systemic disease, is a rare malignancy. Diagnosis of this entity is usually difficult, as it may appear similar to other lymphoid diseases, such as nodular lymphocyte-predominant Hodgkin's lymphoma and classic Hodgkin's lympho-ma. Accurate diagnosis requires careful immunohistochemical analysis of the tumour cells and the inflammatory microenvironment. Like other Diffuse Large B Cell Lymphomas, TCRBCLs follow an aggressive clinical course, and patients should be treated aggressive-ly. We are reporting this case because it is a rare case and to emphasize on the role of immu-no-histochemistry for differentiation, accurate diagnosis and prompt aggressive treatment of TCRBCL.
Key words: T cell rich B cell Lymphoma (TCRBCL) of breast, Immunohistochemistry.
Abstract Id: YUGP1784
Cytotoxic Effect Of Adenanthera Pavonina Seed Extracts On Cancer And Normal Cell Lines
Author- *Mr. Ashish Nair
Co-author - Devi Arikketh, Ayisha Basheer Vakkath, Kartik Sachdeva
Adenanthera Pavonina is a tropical tree which is of religious importance in Kerala and of medical importance in Ayurveda. It is colloquially called as â€œManjadikuruâ€ and several research papers state its blood pressure lowering effect and anti-diabetic effect. My team was interested to analyze the effect of crude seed extract on cancer cells. Methanolic extraction was performed at 50% and 100% concentration of boiled and unboiled crude Manjadikuru seed extracts. MTT Assay was performed and IC50 values were analyzed with respect to the boiled and unboiled crude seed extracts on HepG2 (cancerous) cell line and HEK (normal) cell line. Cytotoxic effect was expected to be higher in HepG2 than in HEK; but as per the IC50 values of MTT Assay the effect was more in HEK than HepG2 cell line. Cytotoxic activity is evident in cancer cell line (HepG2) and normal cell line (HEK). Boiled samples were safer than unboiled samples as per the IC50 values of cancer (HepG2) and normal (HEK) cell lines respectively. This paves way for a higher potential for further research on other cell lines and relevant cytotoxicity assays. IC50 (mg/ml) (boiled/unboiled) : 464.5849/266.7395; 337.15/76.15
Abstract Id: YUGP4260
A Prospective Randomized Study For Comparison Of Mammographic And Ultrasonographic Features Of Triple-Negative Breast Cancer With Other Breast Cancer Subtypes
Author- *Dr. Pankaj Somani
Co-author - Dr Abdul Rouf Gauri, Dr Shiv Singh Meena, Dr Raj Govind Sharma
Introduction – Breast cancer is the most commonly occurring cancer in females worldwide. It is commonest cancer of urban Indian women and second commonest in the rural women. Among these huge number of cases, Triple-negative (TN) breast cancers have high malignancy potential and are often characterized by early systemic relapse. Early detection is vital, but there are few comprehensive imaging reports. Here we describe mammography and ultrasound findings of TN breast cancers, investigate the specific features of this subtype, and compare the characteristics of TN breast cancers with those of Non Triple – Negative breast cancers. Triple-negative breast cancers generally occur in young women and they have the potential to be aggressive. It is important for this subtype of tumour to be detected early. Basis of my study - To study whether there are any peculiar Radiographic feature (on ultrasound & mammography) which can differentiate between Triple Negative Breast cancers from other subtypes? Materials and Methods – This is a Hospital based randomized prospective type of Observational study. The study is being conducted in S.M.S. Hospital, Jaipur in Department of Surgical Oncology. Duration of Study is From June 2015 to June 2017. Total 183 cases were studied. Thorough analysis was done of Sonographic and Mammographic findings of all Breast Cancer patients and comparison is made among the groups (Triple Negative v/s Non Triple Negative). Results – Among the studied 183 patients, 48 were Triple – Negative while remaining 135 were of other subtypes. On mammography TN breast cancer were more likely to show Lobulated shape, heterogenous density, microlobulated margins, non calcified lesions, asymmetrical densities and architectural distortion. On USG, TN breast cancer were more likely to show lobulated shape, microlobulated margins, hypoechoic lesions with hyperechoic halo, posterior acoustic enhancement, increased Doppler vascularity and axillary lymph node positivity. Conclusions – On mammography the triple negative breast cancer is characterised by heterogeneously dense, lobulated shaped, non calcified masses with microlobulated margins, asymmetrical densities and architectural distortion. On USG TN tumors are seen as a lobulated hypoechoic masses with hyperechoic halo, micro lobulated margins having posterior acoustic enhancement, increased Doppler vascularity and axillary lymph node positivity. The radiologist must be aware that this subtype of cancer is having peculiar morphological features on imaging. Improved recognition and detection on mammography and ultrasound imaging should add to a better understanding of the biological behaviour of the disease entity and should lead to rapid pre-treatment planning. Implication for Practical Purpose This study is to describe findings on mammography & ultrasound for TN breast cancers in comparison with other subtypes. As Triple-negative breast cancer largely represents a subtype of breast tumors with unique molecular and clinical characteristics, distinctive risk factors and patterns of recurrence, association with BRCA1 mutation status, inferior prognosis, and expanding therapeutic options. Several distinctive morphological features of these aggressive tumors
Abstract Id: YUGP4302
Giant Soft Tissue Sarcoma Of Neck In A 45 Years Old Female – Largest Ever Reported In Medical Literature: A Case Report And Review Of Literature
Author-*Dr. Pankaj Somani
Co-author - Dr Abdul Rouf Gauri, Dr Shiv Singh Meena, Dr Raj Govind Sharma
Abstract: A soft tissue sarcoma of neck is a rare entity with sarcoma purely confined to neck is even a greater rarity. We report a case of giant soft tissue sarcoma of neck in a 45 years old female of undifferentiated mesenchymal variety which was managed by angio-embolization followed by marginal resection of the tumour, while preserving the vital structures in the neck, and post operative radiotherapy with a 12 months follow up. This is a rare case of giant soft tissue sarcoma purely confined to neck. The case report also validates the need of multidisciplinary approach in the management of soft tissue sarcoma of neck and surgical excision being the primary treatment modality combined with radiotherapy with and without chemotherapy. ? ? Case Presentation: A 45 years old female presented to Sawai Man Singh Hospital, Jaipur, Rajasthan, with a huge swelling on her right side of neck, gradually increasing for the last 4 years. She also complained of dull aching pain in the swelling for the last 15 days with no radiation of pain. Before coming to our institute, she went to a hospital in her locality 4 years back for a swelling in the right upper neck and got it excised, thereafter swelling reappeared after about 3 months of excision. When she came to our observation, the swelling was extending vertically from right ear lobule to the right clavicle, and horizontally from right border of trachea to the right paravertebral area posteriorly (Figure 1, 2, 3) with mild degree of torticollis to left. The right carotid pulsation was not appreciable. The size of the swelling was 18 cm in its greatest vertical extension and 16cm in its greatest horizontal extension. No lymphadenopathy was apparent on neck examination. The chest x- ray revealed shifting of trachea to the left by the mass in the neck (Figure 4). Fiber-optic laryngoscopy showed bulging of the right pharyngeal wall towards midline with normal vocal-chords and glottic space. The Magnetic Resonance Imaging (MRI) revealed a large mass at right neck extending into the right supraclavicular and infraclavicular area.(Figure 5, 6, 7). The core needle biopsy of the patient showed a spindle cell neoplasm with prominent haemangiopericytomatous pattern overall morphology is that of malignant undifferentiated neoplasm. The Immunohistochemistry (IHC) report showed neoplastic cells positive for Vimentin and S100 while negative for Cytokeratin (CK), Smooth Muscle Actin (SMA) and CD34 which favoured it to be as malignant mesenchymal neoplasm. The CT Carotid Angiography showed a large mass on right side the neck abutting right common carotid, internal and external carotid artery (Figure 8). The patient was subjected for angio-embolization of the neck mass using a 6 Fr catheter through femoral artery to the right external carotid vessel, a branch of this artery was the feeding vessel which was embolised successfully using gel foam. The patient was prepared for surgery for excision of mass which was done after raising the skin flap making a T-shaped incision (Figure 9, 10, 11). The right sternocleidomastoid muscle, right external jugular vein were sacrificied but the right carotid vessel, spinal accessory nerve, vagus nerve and right phrenic nerve were preserved (Figure 12). Moreover there was no injury to the cervical sympathetic chain evident as following surgery the signs of Horners Syndrome were absent. Post-operative period was uneventful, she was started with oral feeds after about 8hours following surgery and the vacuum suction drain was removed on post operative day 7. The histopathological examination showed a high grade, spindle cell neoplasm with the mass reaching upto the margins. The IHC report showed cells positive for Vimentin and focally positive for S100. Scattered cells are positive for CD68. Negative for SMA, CD34, Desmin, CK7 and EMA. This favoured possibility of either Malignant peripheral nerve sheath tumour or Undifferentiated malignant mesenchymal tumour. After about 6 months of follow up patient is doing good with no torticollis, no signs of horners syndrome, facial palsy, phrenic nerve palsy, spinal accessory nerve palsy or any signs of recurrence of the tumour. But at 9 months post op, she presented to us with metastatic deposit in bilateral lungs in contrast enhanced CT scan of Thorax for which later on she was subjected to chemotherapy also. Discussion: Head and neck soft tissue sarcomas (HN-STS) are rare mesenchymal malignant neoplasms accounting for < 10% of all soft tissue sarcomas and approximately 1% of all head & neck neoplasms. STS show a biphasic age distribution—80 - 90% affect adults and 10-20% are seen in paediatric population. The most common symptom of HN-STS is a painless mass. Examination generally reveals a subcutaneous mass of neck possibly with distortion or destruction of the adjacent structure. Tumors of neck can impinge on the vital structures, causing dysphagia, hoarseness and even dyspnoea. A detailed history and physical examination play a major role in the diagnosis. Imaging plays a major role in defining the extent of the tumor to nearby vital structures for treatment planning and deciding surgical approach. Magnetic resonance imaging (MRI) is generally superior to computed tomography (CT) scans in soft tissue sarcomas. CT scan is preferred to assess bone involvement. Positron emission tomography (PET) using fluorodeoxyglucose (FDG) is to grade the tumour. Histological examination of a biopsy specimen can lead to a definitive diagnosis (11). Fine needle aspiration cytology (FNAC) is an easy, fast and cheap technique. Core needle/Trucut biopsy provide enough tissues for accurate histopathological studies and grading. Excisional biopsies should be reserved for selected masses smaller than 3 cm in diameter (11)(11). For deep seated tumor or those near vital structures, ultrasound or CT Scan guided biopsies are recommended. Complete surgical resection of sarcomas in the parotid, neck, and parapharyngeal space is preferable to incisional biopsy if the FNA is non-diagnostic. The classical treatment modalities employed in HN-STS are: surgery, radiotherapy and/or chemotherapy. Adequate surgical excision is not applicable in most of HN-STS due to the complex anatomy and close proximity of major vital structures to primary tumor hence, resection of gross tumor with postoperative adjuvant therapy is the treatment of choice in most cases (27). Radiotherapy in HN-STS is indicated in high grade sarcomas, positive surgical margins, lesions larger than 5 cm and recurrent lesions (27). Chemotherapy provides improved local control especially if combined with radiation therapy. Indications of chemotherapy are unresectable HN-STS with extension to the unusual locations (skull base), high grade sarcomas and aggressive sarcomas (27). Conclusion: HN-STS are rare malignancies and giant STS of neck region being even rarer. Herein we report a case of giant STS of head & neck region which underwent a marginal resection. The difficulty in resecting such a big mass is attributed to the anatomical complexity and proximity of vital structures in the neck. Till date only few cases of giant soft tissue sarcoma of neck have been reported in literature and still few of them have been managed by surgical resection. We present a case of giant soft tissue sarcoma in neck which was managed by surgery and post operative radiotherapy.
Abstract Id: YUGP1048
Cancer Profile In Jakarta Province Region 2008 - 2012: Based On Data At Ciptomangunkusumo Hospital As Controlling Center For Cancer Registration Of Jakarta Province
Authors - Febryono Basuki Raharjo, Denny Handoyo, Dion Firli, Fathiya Juwita Hanum, Montesqieu Silalahi, Wahyudi Nurhidayat, Soehartati Gondhowiardjo
Background: According to WHO (World Health Organization) data in 2012, cancer occupies the second cause of death in developed countries after cardiovascular disease and become the third leading cause of death in developing countries after cardiovascular and infectious diseases. Currently, data on cancer profiles obtained from cancer registration activitie s in Indonesia does not exist. Cancer profiles with good collecting and reporting methods are required for the establishment of Indonesia population-based cancer registry. The Minister of Health of Indonesia has designated Ciptomangunkusumo Hospital as a control center for cancer registration of Jakarta Province. This study aims to provide a description of cancer profile of Jakarta Province in 2008 to 2012 based on data from Ciptomangunkusumo Hospital as a control center for cancer registration of Jakarta Province. Methods: This was a cross sectional descriptive study by collecting data from cancer registry at Ciptomangunkusumo Hospital to establish cancer profile in Jakarta Province in 2008 to 2012. Results: 14,726 cancer patients were found, with male and female ratio of 1: 1.8. The majority of patients are between 45-54 years old. Most of patients came to the health care facility were in advanced stage, as many as 31.8%. The number of patient is highest from West Jakarta (27.5%) and followed by from East Jakarta (25.5%). The five most frequent cancer found in both sexes were breast cancer, cervical cancer, hematopoietic and reticuloendothelial system malignancy, lung and bronchial cancer, and nasopharyngeal cancer. The five most common cancers in male were lung cancer, nasopharyngeal cancer, hematopoietic and reticuloendothelial system malignancy, liver cancer, and lymph node cancer. The five most common cancers in female were breast cancer, cervical cancer, ovarian cancer, hematopoietic and reticuloendothelial system malignancy, and thyroid gland cancer. Conclusion: The results of this study are similar with GLOBOCAN 2012 results for Southeast Asia region, but the data coverage was still not optimal because not all health care facilities in Jakarta submitted cancer patients data. Suggestion: Further research is needed with broader coverage involving all health care facilities in the Province of Jakarta. Keywords: cancer, cancer profile, cancer registration, Jakarta Province
Abstract Id: YUGP1022
Cancer Epidemiology Profile Based On Hospital Based Cancer Registry At Cipto Mangunkusumo National General Hospital Year 2008-2013
Authors - Ngakan Putu Daksa Ganapati, Nadia Christina, Ericko Ekaputra, Kartika Erida Brohet, Adjie Kusumadjati, Lidya Meidania, Soehartati Gondhowiardjo,
Introduction: Cancer registration defined as a continous process in a systematic data collection on the incidence and characteristics of the neoplasm It can provide basic data for cancer research and help policymaker to determine hospital policy related to cancer. Materials and Methods: This study was a cross sectional descriptive study of all registered cancer patients on Hospital Based Cancer Registry (HBCR) from January 2008-December 2013 in Cipto Mangunkusumo National General Hospital (RSCM). Results: The result was as follows: the number of cancer cases in RSCM during 2008-2013 were 23,818 cancer cases. The number of male patients compared with female was 1:1.7. The majority of patients aged was 45-54. The most frequent job was housewive and most of patients came from outside of Jakarta, than from Jakarta. Cervical cancer, breast cancer, hematopoietic and reticuloendothelial systems malignancies, nasopharynx cancer and lymphnodes malignancies were the most common cancer type. For female, the most common cancer cases were : cervical, breast, ovarian, hematopoietic and reticuloendothelial systems and thyroid. For male, the most common cancer cases were nasopharynx, hematopoietic and reticuloendothelial systems, lymph nodes, liver and skin. The staging disease data in this study was very low due to inadequate medical report recording. Most common Histopathological type were: non keratinized squamous cell carcinoma (cervical), invasive ductal carcinoma (breast), non keratinized squamous cell carcinoma (nasopharynx), acute lymphoblastic leukemia (hematopoietic and reticuloendothelial systems), and lymphoma-non hodgkin (lymphnodes). Conclusion: This study showed that overall cancer patients in Cipto Mangunkusumo National General Hospital year 2008-2013 were similar with patients profile in prior HBCR studies.
Abstract Id: YUGP0811
reatment And Cosmetic Results In Indonesian Woman With T1-2N0 Breast Cancer Treated With Breast-Conserving Treatment
Authors - Rafiq Sulistyo Nugroho, Ratnawati Soediro, Nurjati Chaerani Siregar, Zubairi Djoerban, Evert DC Poetiray, Soehartati Gondhowiardjo
Background: To obtain the breast conserving treatment (BCT) outcomes compare to mastectomy for Indonesian women with T1-2N0 breast cancer and evaluate its cosmetic result. Methods: This study retrospectively reviewed T1-2N0 breast cancer patients who received treatment between January 2001 and December 2010 at Department of Radiotherapy Cipto Mangunkusumo Hospital and Jakarta Breast Center. The endpoints of this study were overall survival (OS), local recurrence (LR), contra-lateral breast cancer (CBC), distant metastasis (DM), disease-free survival (DFS) and cosmetic outcome according to harvard Score. Results: Among the 262 eligible patients, 200 (76.3%) patients underwent BCT while 62 (23.7%) patients underwent mastectomy. There were no differences between BCT and mastectomy groups in 5-Y OS (88.2% vs 86.7%, p = 0,743), LR (7.4% vs 2.7%, p = 0.85), CBC (3.4% vs 5.3%, p = 0.906), DM (17.7% vs 37.7%, p = 0.212), and DFS (78.5% vs 60.7%, p = 0.163). In multivariate analysis, grade 3 was associated with worse OS (HR 2.79; 95% CI 1.08 â€” 7.21, p = 0.03) and DFS (HR 2.32; 95% CI 1.06 â€” 5.06). Premenopausal women were associated with decreased risk of DM (HR 0.37; 95% CI 0.17 â€” 0.80) and DFS (HR 0.38; 95% CI 0.19 â€” 0.78). Among a hundred and three patients who had performed cosmetic evaluation, 59 (57.3%) patients had excellent â€” good, 9 (8.7%) patients had fair and 35 (34%) patients had poor cosmetic outcome. Conclusion: BCT and mastectomy showed similar outcome in terms of OS, LR, CBC, DM, and DFS. Almost 60 percents of patients treated with BCT had favorable cosmetic result. Keywords: Breast-conserving treatment, mastectomy, cosmetic, result