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ORIGINAL ARTICLE
Year : 2019  |  Volume : 15  |  Issue : 5  |  Page : 1062-1066

Thiol-disulfide homeostasis in breast cancer patients


1 Department of General Surgery, Training and Research Hospital, University of Health Sciences, Konya, Turkey
2 Department of Anesthesiology, Training and Research Hospital, University of Health Sciences, Konya, Turkey
3 Department of Family Medicine, Training and Research Hospital, University of Health Sciences, Konya, Turkey
4 Department of Biochemistry, Training and Research Hospital, University of Health Sciences, Konya, Turkey
5 Department of Biochemistry, Yildirim Beyazit University, Ankara Atatürk Training and Research Hospital, Ankara, Turkey

Correspondence Address:
Ibrahim Solak
Department of Family Medicine, University of Health Sciences, Training and Research Hospital, Konya
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_553_17

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Objective: The aim of our study is to assess thiol-disulfide homeostasis (TDH), which is a biomarker of systemic oxidative stress, in breast cancer patients. Materials and Methods: Thirty-seven breast cancer patients and 31 age-matched healthy volunteers were enrolled in this study. Serum native thiol, disulfide, and total thiol levels and disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were analyzed using a novel colorimetric method. Results: Serum native thiol level was statistically significantly lower in breast cancer patients (350.39 ± 7.15) than in healthy controls (380.60 ± 7.35) (P = 0.008). Serum disulfide level was statistically significantly higher in breast cancer patients (24.96 ± 0.85) than in healthy controls (19.25 ± 1.34) (P = 0.002). Conclusion: To our knowledge, this study is the first study in the literature that investigated TDH in breast cancer patients. We have concluded that an alteration in TDH due to oxidative stress is likely to have a role in the pathogenesis of breast cancer.


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