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ORIGINAL ARTICLE
Year : 2019  |  Volume : 15  |  Issue : 2  |  Page : 350-357

Chromatin remodeling factor lymphoid-specific helicase links with Epstein-Barr virus associated the follicular germinal center B cell lymphomas


1 Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
2 Department of Pathology, School of Basic Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
3 Center for Medicine Research, Xiangya Hospital, Central South University, Changsha, Hunan, China
4 Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, School of Basic Medicine, Cancer Research Institute, Central South University, Changsha, Hunan, China

Correspondence Address:
Dr. Desheng Xiao
Department of Pathology, Xiangya Hospital; Department of Pathology, School of Basic Medicine, Central South University, Changsha 410078, Hunan
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_243_18

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Background: We assessed the frequency of epigenetic lesions, including lymphoid-specific helicase (LSH), 5-hydroxymethylcytosine (5-hmC) and E2F1, and the possible correlations among molecular findings, phenotype, clinical features, and outcome. Methods: We investigated 181 paraffin-embedded B-cell lymphoma samples using immunohistochemistry and in situ hybridization. Results: The levels of Ki67, LSH, 5-hmC, and E2F1 were all increased in germinal center B-cell lymphomas when compared with those in normal lymph nodes, and LSH was highly expressed in diffuse large B-cell lymphomas (DLBCLs) and Burkitt lymphomas (BLs) that were positive for Epstein-Barr virus (EBV) infection, indicating that LSH is linked to EBV infection in DLBCL and BL. Interestingly, LSH was mainly localized in the germinal centers of lymph nodes whereas 5-hmC staining localized to areas surrounding the germinal centers. Conclusions: These findings indicate a critical role for LSH as a biomarker and therapeutic target in follicular germinal center B-cell lymphoma.


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