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ORIGINAL ARTICLE
Year : 2019  |  Volume : 15  |  Issue : 2  |  Page : 317-323

Receptors for advanced glycation end products is associated with autophagy in the clear cell renal cell carcinoma


1 Department of Urology, Shanghai Tenth People's Hospital of Nanjing Medical University, Nanjing; Transplantation Centre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2 Department of Pathology, The Fifth Hospital of Shijiazhuang, Shijiazhuang, China
3 Department of Urology, Shanghai Tenth People's Hospital of Nanjing Medical University, Nanjing, China
4 Department of Urology, Shanghai General Hospital of Nanjing Medical University, Nanjing; Department of Urology, The Affiliated First People's Hospital of Shanghai Jiao Tong University, Shanghai, China

Correspondence Address:
Dr. Jun-Hua Zheng
No. 101, Longmin Street, Nanjing Medical University, Jiangning, Nanjing 211166
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_180_18

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Background: The receptor for advanced glycation end-product (RAGE) was one of the signal transduction receptors. RAGE interacted with various signaling molecules which were involved in human disease processes including tumorigenesis. Previous reports have indicated that RAGE/high-mobility group box 1 (HMGB1) could regulate autophagy in different carcinomas. However, the functional role of RAGE/ HMGB1 in the regulation of clear cell renal cell carcinoma (ccRCC) autophagy remained unrevealed. Methods: Western blot, quantitative real-time polymerase chain reaction (qRT-PCR) and immunofluorescence were used in the present study. Results: In this study, we demonstrated that the levels of RAGE/HMGB1 and autophagic protein LC3, Beclin-1, PI3K were much higher in ccRCC samples than those of in adjacent normal tissues. RAGE and autophagic protein expression was regulated with RAGE/HMGB1 in human RCC cell lines. Conclusion: Our results implicated that RAGE and autophagy played important roles in ccRCC, and RAGE/HMGB1 might serve as a novel therapeutic target for future ccRCC treatment.


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