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ORIGINAL ARTICLE
Year : 2019  |  Volume : 15  |  Issue : 1  |  Page : 231-236

Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model


1 Department of Biology, Faculty of Science, Mustafa Kemal University, Antakya, Turkey
2 Department of Environmental Engineering, Faculty of Engineering and Architecture, Nevsehir Haci Bektas Veli University, Nevsehir, Turkey
3 Department of Biology Education, Ahmet Kelesoglu Faculty of Education, Necmettin Erbakan University, Konya, Turkey

Correspondence Address:
Dr. Erkan Kalipci
Department of Environmental Engineering, Faculty of Engineering and Architecture, Nevsehir Haci Bektas Veli University, Nevsehir
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_1319_16

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Aim: The effect of acetylsalicylic acid (ASA) on thiol levels was studied in a rat model of azaserine carcinogenesis. Materials and Methods: ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (–SH) content and variations in free and protein-bound molecules containing the –SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period. Results: Changes in the hepatic, pancreatic, and renal –SH contents were also determined. Conclusion: Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound –SH.


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