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ORIGINAL ARTICLE
Year : 2018  |  Volume : 14  |  Issue : 9  |  Page : 526-532

Association of cytotoxic T-lymphocyte antigen 4 rs231775 gene polymorphism with colorectal cancer risk


1 Department of Interventional Oncology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
2 Department of Gastrointestinal Surgery, The Affiliated Hospital of Putian University, Putian 351100, China

Correspondence Address:
Zhiyong Dong
Department of Gastrointestinal Surgery, The Affiliated Hospital of Putian University, Putian 351100
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.191065

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Aim of the Study: Results on the relationship between cytotoxic T-lymphocyte antigen 4 (CTLA4) +49A/G (rs231775) gene polymorphism and colorectal cancer risk are still debated. This meta-analysis was performed to assess the association between CTLA4 +49A/G and colorectal cancer risk. Materials and Methods: The relevant studies were searched from PubMed, Cochrane Library, and China Biological Medicine Database-disc, and eligible investigations were included and synthesized using meta-analysis method. Results: Eleven studies were recruited into this meta-analysis for the association of CTLA4 A/G gene polymorphism and colorectal cancer risk, consisting of 1802 colorectal cancer patients and 2939 controls. G allele was a risk factor for the colorectal cancer risk, and AA genotype might be a protective factor against colorectal cancer risk in overall populations (G allele: Odds ratio [OR] = 1.19, 95% confidence interval [CI]: 1.03–1.38, P = 0.02; AA genotype: OR = 0.63, 95% CI: 0.47–0.84, P = 0.002). However, the GG genotype was not associated with colorectal cancer risk in overall populations. Conclusion: The association between CTLA4 G allele/AA genotype and colorectal cancer risk was found in this meta-analysis.


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