|Year : 2018 | Volume
| Issue : 9 | Page : 516-518
CCND1 rs9344 polymorphism is associated with the risk of hepatocellular carcinoma in Caucasian population
Da-dong Wang1, Wei-dong Duan2, Zi-man Zhu1, Yu-liang Tu1, Chun-qing Dou1, Ming-ming Han1, Bao Zhang1, Wei Zhao1, Kai Jiang2
1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China
2 Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China
|Date of Web Publication||29-Jun-2018|
Department of Hepatobiliary Surgery of Chinese PLA General Hospital, No. 28, Fuxing Road, Beijing 100853,
Source of Support: None, Conflict of Interest: None
Aims: Some studies investigated the association between CCND1 rs9344 polymorphism and hepatocellular carcinoma (HCC) risk. However, the results were inconclusive. Thus, we did a meta-analysis to determine this relationship.
Materials and Methods: Relevant studies were systematically searched using the PubMed, CNKI, and EMBASE databases. The strength of the association was calculated with the odds ratio (OR) and respective 95% confidence intervals (Cis).
Results: We investigated the association between CCND1 rs9344 polymorphism and HCC risk in the dominant models. The result of this meta-analysis showed that CCND1 rs9344 polymorphism did not significantly associated with HCC risk (OR = 1.09; 95% CI 0.88–1.34). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with HCC risk in Caucasians (OR = 1.55; 95% CI, 1.05–2.29). However, we did not find any significant association between this polymorphism and HCC risk in Asians (OR = 0.91; 95% CI, 0.71–1.18).
Conclusions: This meta-analysis suggested that CCND1 rs9344 polymorphism might be associated with the risk of HCC among Caucasians.
Keywords: CCND1, hepatocellular carcinoma, polymorphism
|How to cite this article:|
Wang Dd, Duan Wd, Zhu Zm, Tu Yl, Dou Cq, Han Mm, Zhang B, Zhao W, Jiang K. CCND1 rs9344 polymorphism is associated with the risk of hepatocellular carcinoma in Caucasian population. J Can Res Ther 2018;14, Suppl S2:516-8
|How to cite this URL:|
Wang Dd, Duan Wd, Zhu Zm, Tu Yl, Dou Cq, Han Mm, Zhang B, Zhao W, Jiang K. CCND1 rs9344 polymorphism is associated with the risk of hepatocellular carcinoma in Caucasian population. J Can Res Ther [serial online] 2018 [cited 2019 Nov 16];14:516-8. Available from: http://www.cancerjournal.net/text.asp?2018/14/9/516/235437
| > Introduction|| |
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide. HCC is the fifth most commonly occurring solid tumor worldwide, with relatively high and increasing incidence as well as frequent relapse and dismal prognosis.
CCND1 gene, located on chromosome 11q13, encodes the key cell cycle G1 regulatory protein CyclinD1, which promotes the phosphorylation of retinoblastoma protein and other substrates by binding to cyclin-dependent kinase 4/6 to make cells proliferation rapidly. Overexpression of CCND1 is frequently observed in a variety of tumors including epithelial ovarian cancer, colorectal cancer, liver cancer, gastric cancer, nasopharyngeal carcinoma, and lung cancer resulting in altered cell cycle progression which contributes to tumorigenesis.
Some studies investigated the association between CCND1 rs9344 polymorphism and HCC risk.,,,,, However, the results were inconclusive. Thus, we did a meta-analysis to determine this relationship.
| > Materials and Methods|| |
Relevant studies were systematically searched using the PubMed, CNKI, and EMBASE databases (the last retrieval date was March 22, 2016, using the search terms: “Cyclin D1 or CCND1” and “HCC”). All searched studies were retrieved and only published studies with full-text articles were included in the study. When more than publications with duplicate samples, only the newest study was used in this research.
Inclusion and exclusion criteria
The inclusion criteria were as follows: (1) the diagnosis of HCC was confirmed by pathology; (2) the research was a case–control study or a cohort study; (3) the study focused on the association between CCND1 rs9344 polymorphism and HCC risk; and (4) the CCND1 rs9344 polymorphism of individual groups were provided. The exclusion criteria were as follows: (1) the HCC patients were not confirmed by pathology, (2) animal studies, and (3) reviews or abstracts.
The following data were recorded from each article:First author, years of publication, ethnicity of participants, numbers of cases and controls. The data were extracted by two of the authors independently. Discrepancies between these two authors were resolved by discussion.
The strength of association was assessed by calculating the odds ratio (OR) with 95% CI. The pooled ORs were performed for dominant model. Departure from Hardy–Weinberg equilibrium in controls was tested by the Chi-square test. A statistical test for heterogeneity was performed based on the Q-statistic. The P > 0.10 of the Q-test indicated a lack of heterogeneity among studies. Stratified analysis was performed by ethnicity. Potential publication bias was examined by Egger test. All statistical tests were performed with the software STATA version 11.0 (Stata Corporation, College station, TX, USA). A P < 0.05 was considered statistically significant.
| > Results|| |
Six studies met the inclusion criteria and were included in the final analysis. One study reported three case–control studies. Therefore, 1018 HCC patients and 1297 controls were included in the study. Four studies included Asian population; two studies were performed in Caucasians. The characteristics of included studies were summarized in [Table 1].
We investigated the association between CCND1 rs9344 polymorphism and HCC risk in the dominant models. The result of this meta-analysis showed that CCND1 rs9344 polymorphism did not significantly associated with HCC risk (OR = 1.09; 95% CI 0.88–1.34). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with HCC risk in Caucasians (OR = 1.55; 95% CI, 1.05–2.29). However, we did not find any significant association between this polymorphism and HCC risk in Asians (OR = 0.91; 95% CI, 0.71–1.18). No significant publication bias was found by Egger test (data not shown).
| > Discussion|| |
This meta-analysis suggested that CCND1 rs9344 polymorphism was not significantly associated with HCC risk. Subgroup analyses based on ethnicity was conducted. CCND1 rs9344 polymorphism was associated with increased risk of HCC among Caucasians. However, no such result was found in Asians.
Fusté et al. suggested that the role of CCND1 in the cytoplasm is mainly associated with the invasive capability of tumor cells. Yilmaz et al. indicated that downregulation of CCND1 expression may be an important mechanism by which everolimus increases the therapeutic window of paclitaxel in cervical cancers. Li et al. found that loss expression of CCND1 might be an important event in the tumorigenesis in basal-like breast cancers. Xu et al. reported that increased nuclear CCND1 is a potential unfavorable prognostic factor for lung adenocarcinoma patients, especially those with the clinical early stage.
There were some limitations in this meta-analysis. First, lack of the original data limited the evaluation of gene-gene and gene-environment interactions. Second, we did not adjust other factors in this meta-analysis due to lack of the original data. Third, the studies included in our meta-analysis were small. Thus, our meta-analysis had little statistical power.
| > Conclusions|| |
This meta-analysis suggested that CCND1 rs9344 polymorphism might be associated with the risk of HCC among Caucasians.
Financial support and sponsorship
This study is supported by Beijing Municipal Science and Technology Commission (No. Z151100003915155).
Conflicts of interest
There are no conflicts of interest.
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