Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 14  |  Issue : 9  |  Page : 490-493

MiR-499 rs3746444 polymorphism and hepatocellular carcinoma risk: A meta-analysis


Department of Hepato-Biliary- Pancreatic Surgery, Henan Tumor Hospital (The Cancer Hospital Affiliated to Zhengzhou University), Zhengzhou 450008, Henan, China

Correspondence Address:
Feng Han
Department of Hepato-Biliary-Pancreatic Surgery, Henan Tumor Hospital (The Cancer Hospital Affiliated to Zhengzhou University), No. 127, Dongming Road, Zhengzhou 450008, Henan
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.179090

Rights and Permissions

Aims: Several studies suggested that miR-499 rs3746444 polymorphism was associated with the risk of hepatocellular carcinoma (HCC). However, other studies did not confirm the result. To derive a more comprehensive estimation of the association between miR-499 rs3746444 polymorphism and HCC risk, we conducted a meta-analysis. Materials and Methods: PUBMED, COCHRANE, and WEB OF SCIENCE databases were retrieved for the association studies focused on the relationship between miR-499 rs3746444 polymorphism and the risk of HCC. The strength of the associations between miR-499 rs3746444 polymorphism and the risk of HCC was measured by odds ratios (ORs) with 95% confidence intervals (CIs). Results: A statistically significant association between miR-499 rs3746444 polymorphism and the risk of HCC was fond (OR = 1.26; 95% CI, 1.04–1.52; P = 0.02). In the subgroup analysis of race, Asian population with miR-499 rs3746444 polymorphism showed increased HCC risk (OR = 1.29; 95% CI, 1.03–1.62; P = 0.03). In the subgroup analysis of hepatitis virus status, patients with HBV and miR-499 rs3746444 polymorphism showed increased HCC risk (OR = 1.38; 95% CI, 1.17–1.64; P = 0.0002). In the subgroup analysis of source of control, both hospital- and population-based studies found significant results (OR = 1.46; 95% CI, 1.12–1.90; P = 0.005; OR = 1.19; 95% CI, 1.01–1.40; P = 0.04). Conclusions: This meta-analysis suggested that mir-499 rs3746444 polymorphism was associated with an increased HCC risk.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2026    
    Printed63    
    Emailed0    
    PDF Downloaded56    
    Comments [Add]    

Recommend this journal