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Year : 2018  |  Volume : 14  |  Issue : 3  |  Page : 578-582

Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)

1 Department of Medical Oncology, Mersin Hospital, Mersin, Turkey
2 Department of Medical Oncology, Trakya University, Edirne, Turkey
3 Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, İstanbul, Turkey
4 Department of Medical Oncology, Erciyes University, Kayseri, Turkey
5 Department of Medical Oncology, Cumhuriyet University, Sivas, Turkey
6 Department of Medical Oncology, Kayseri Numune Education and Research Hospital, Kayseri, Turkey
7 Department of Medical Oncology, Inonu University, Malatya, Turkey
8 Department of Medical Oncology, Gazi University, Ankara, Turkey
9 Department of Medical Oncology, Celal Bayar University, Manisa, Turkey
10 Department of Medical Oncology, Karadeniz Teknik University, Trabzon, Turkey
11 Department of Medical Oncology, Dicle University, Diyarbakir, Turkey
12 Department of Medical Oncology, İstanbul University, İstanbul, Turkey
13 Department of Medical Oncology, Atatürk University, Erzurum, Turkey
14 Department of Medical Oncology, Okmeydanı Education and Research Hospital, İstanbul University, İstanbul, Turkey
15 Department of Medical Oncology, Konya Numune Hospital, Konya, Turkey
16 Department of Medical Oncology, Mersin University, Mersin, Turkey
17 Department of Medical Oncology, Ankara Numune Education and Research Hospital, Turkey
18 Department of Medical Oncology, Sakarya University, Sakarya, Turkey
19 Department of Medical Oncology, Gaziosmanpasa University, Yozgat, Turkey
20 Department of Medical Oncology, Ankara Onkoloji Education and Research Hospital, Turkey
21 Department of Medical Oncology, Afyon Kocatepe University, Afyon, Turkey
22 Department of Medical Oncology, Mugla Sıtkı Kocman University, Mugla, Turkey
23 Department of Medical Oncology, Bezmialem Vakif University, İstanbul, Turkey
24 Department of Medical Oncology, Haydarpasa Numune Education and Research Hospital, İstanbul, Turkey
25 Department of Medical Oncology, Gaziantep University, Gaziantep, Turkey
26 Department of Medical Oncology, Kent Hospital, İstanbul, Turkey

Correspondence Address:
Ali Inal
Department of Medical Oncology, Mersin State Hospital, Mersin
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.176417

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Purpose: Almost half of all patients diagnosed with non-small cell lung cancer (NSCLC) have distant metastases at presentation. One-third of patients with NSCLC will have brain metastases. Without effective treatment, the median survival is only 1 month. However, it is difficult to treat brain metastases with systemic chemotherapy since the agents have difficulty crossing the blood-brain barrier. Therefore, it is important to estimate the patient's survival prognosis. The aim of this study was to analyze prognostic factors for survival in Turkish patients who received chemotherapy after cranial irradiation for NSCLC with brain metastases. Methods: We retrospectively reviewed 698 patients with brain metastases resulting from NSCLC. Ten potential prognostic variables were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors associated with overall survival (OS). Results: Among the 10 variables for univariate analysis, six were identified to have prognostic significance; these included sex, smoking history, histology, number of brain metastases, extracranial metastases, and neurosurgical resection. Multivariate analysis by the Cox proportional hazard model showed that a smoking history, extracranial metastases, and neurosurgical resection were independent negative prognostic factors for OS. Conclusion: Smoking history, extracranial metastases, and neurosurgical resection were considered independent negative prognostic factors for OS. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for more appropriate treatment options.

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