Correlation between epidermal growth factor receptor mutation and histologic subtypes or characteristics of computed tomography findings in patients with resected pulmonary adenocarcinoma
Danyun Wang1, Ning Yan2, Xudong Yang3, Yuan Ge4, Dedong Xu4, Guangyuan Shao5, Zhongmin Peng5
1 Department of Thoracic Surgery, Jinan Center Hospital Affiliated Shandong University, Shandong 250013, P.R. China
2 Department of Urology, Jinan Center Hospital of Jinan, Jinan, Shandong 250013, P.R. China
3 Department of Thoracic Surgery, Qianfo Shan Hospital of Shandong, Jinan, Shandong 250021, P.R. China
4 Department of Anesthesiology, Jinan Center Hospital of Jinan, Jinan, Shandong 250013, P.R. China
5 Department of Thoracic Surgery, Provincial Hospital Affiliated Shandong University, Shandong University, Jinan, Shandong 250021, P.R. China
Dr. Zhongmin Peng
Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Shandong University, 324 Jingwu Road, Jinan, Shandong 250021
Source of Support: None, Conflict of Interest: None
Objective: To investigate the correlation between epidermal growth factor receptor (EGFR) mutation and the histologic subtypes features or computed tomography (CT) findings in patients with resected pulmonary adenocarcinoma.
Materials and Methods: We retrospectively reviewed 153 patients underwent surgical resected pulmonary adenocarcinoma. EGFR mutations were detected using the amplification refractory mutation system. Histologic subtype was classified according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society pulmonary adenocarcinoma classification. Characteristics of CT in the tumor were retrospectively analyzed, and compared to mutation-negative cohort.
Results: EGFR mutations were found in 67 (43.79%) cases. The prevalent histologic subtypes of invasive adenocarcinoma were acinar predominant adenocarcinoma (33.99%), papillary predominant adenocarcinoma (24.18%), micropapillary predominant adenocarcinoma (MPA; 18.95%), solid predominant adenocarcinoma (11.76%), and lepidic predominant adenocarcinoma (LPA; 11.11%). EGFR mutations were correlated with the MPA and LPA subtypes (P = 0.009 and P = 0.018) and was correlated with the air bronchograms (P = 0.008). EGFR mutations were independently associated with other CT characteristics including ground-glass opacity/tumor ratio (P = 0.054).
Conclusions: Correlation exists between EGFR mutations and histologic subtypes of invasive adenocarcinoma or air bronchograms on CT images, which could use to predict EGFR mutation status in patients with pulmonary adenocarcinoma.