|LETTER TO THE EDITOR
|Year : 2017 | Volume
| Issue : 6 | Page : 1074
Middle East respiratory syndrome virus: Is there any carcinogenicity property?
Beuy Joob1, Viroj Wiwanitkit2
1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Department of Troical Medicine, Hainan University, Hainan, China
|Date of Web Publication||13-Dec-2017|
Dr. Beuy Joob
Sanitation 1 Medical Academic Center, Bangkok
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Joob B, Wiwanitkit V. Middle East respiratory syndrome virus: Is there any carcinogenicity property?. J Can Res Ther 2017;13:1074
The Middle East respiratory syndrome (MERS) is a deadly viral infection. The disease cause high mortality. An interesting concern on the causative virus of MERS is the possibility of carcinogenesis. Since MERS is a new disease and there is no long-term clinical data on infected cases, the interesting question is “Is there any carcinogenicity property?” Here, the authors use the bioinformatics technique for predicting. The tool, namely, WAY2DRUG uis used. This tool uses the method, namely, “Prediction of Activity Spectra for Substances technology” in operation. According to the assessment, no carcinogenicity of the MERS virus can be seen in either cancerous and nontumor cell line conditions. Hence, there should be no carcinogenicity property of MERS virus. This finding is concordant with the previous report by Smith et al. that the virus is not a mutagen.
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Conflicts of interest
There are no conflicts of interest.
| > References|| |
Joob B, Wiwanitkit V. MERS-CoV. Oman Med J 2014;29:381.
Pogodin PV, Lagunin AA, Filimonov DA, Poroikov VV. PASS t argets: Ligand-based multi-target computational system based on a public data and naïve Bayes approach. SAR QSAR Environ Res 2015;26:783-93.
Smith EC, Blanc H, Surdel MC, Vignuzzi M, Denison MR. Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: Evidence for proofreading and potential therapeutics. PLoS Pathog 2013;9:e1003565.