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ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 4  |  Page : 642-646

A retrospective analysis of the efficacy of microparticle-mediated chemoembolization in liver metastases arising from gastrointestinal tumors


1 Department of Intervention, The Affiliated Zhongshan Hospital of Dalian University, Dalian, China
2 Department of Hepatopancreatobiliary Interventional Radiology, Beijing Tsinghua Changgeng Hospital, Beijing, China

Correspondence Address:
Jun Zhou
Department of Intervention, The Affiliated Zhongshan Hospital of Dalian University, Dalian
China
Yue-Wei Zhang
Department of Hepatopancreatobiliary Interventional Radiology, Beijing Tsinghua Changgeng Hospital, No. 268, Li Tang Road, Changping District, Beijing
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrt.JCRT_213_17

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Purpose: We evaluated the clinical efficacy of gelatin sponge microparticle (GSM) -mediated chemoembolization for the treatment of patients with liver metastases following surgery for gastrointestinal tumors. Materials and Methods: In a retrospective analysis of 37 patients who were treated at our hospital with GSM-mediated chemoembolization for liver metastases over 13 years, we evaluated outcomes using a modified response evaluation criteria in solid tumors system and also assessed liver function and adverse effects. All patients had previously undergone surgery for gastrointestinal tumors. Results: Treatment produced various degrees of necrosis and shrinkage of lesions among our patients. Two patients achieved a complete response (CR), 27 showed a partial response (PR), five had stable disease, and three had progressive disease. The overall response rate (CR + PR) was 78%, and no severe adverse effects were observed. Conclusion: GSM-mediated chemoembolization showed good clinical efficacy in the treatment of liver metastases after gastrointestinal tumor surgery. However, larger cohort and clinical controlled studies are warranted.


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