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ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 2  |  Page : 257-261

Correlation of serum intercellular adhesion molecule 1 and vascular endothelial growth factor with tumor grading and staging in breast cancer patients


1 Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran
2 Women Reproductive Health Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Pathology, Ardabil University of Medical Sciences, Ardabil, Iran
4 Public Health Department, Ardabil University of Medical Sciences, Ardabil, Iran

Date of Web Publication23-Jun-2017

Correspondence Address:
Amir Vahedi
Women Reproductive Health Center, Tabriz University of Medical Sciences, Tabriz
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.204894

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 > Abstract 

Background: Breast cancer is the most common cancer among women. There are several prognostic factors for this disease. The aim of this article is to explore the correlation of serum level of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule 1 (ICAM1) with tumor, node, metastasis staging and grading of breast cancer.
Materials and Methods: Serum samples of 51 patients with breast cancer were assessed with enzyme-linked immunosorbent assay for the level of VEGF and ICAM1 preoperatively. After the operation, histopathologic specimens stained with hematoxylin and eosin were evaluated for tumor size, histopathologic subtype, grade, lymph node, vascular and lymphatic involvement. Then, the correlation of tumor stage and grade and serum level of markers was analyzed.
Results: There was no significant correlation between serum level of markers with vascular invasions, lymph node involvement, and menstruation. There was a weak correlation between tumor size and serum level of ICAM1 with Pearson score correlation, but there was no significant correlation with VEGF. There was no significant correlation between tumor grading and staging with the level of markers. There was a significant correlation between the level of VEGF and ICAM1 and histologic type of tumors in invasive through in situ tumors.
Conclusion: Levels of VEGF and ICAM1 can be used as a predictor of tumor invasion and also for target therapy.

Keywords: Breast cancer, intercellular adhesion molecule 1, tumor, vascular endothelial growth factor


How to cite this article:
Haghi AR, Vahedi A, Shekarchi AA, Kamran A. Correlation of serum intercellular adhesion molecule 1 and vascular endothelial growth factor with tumor grading and staging in breast cancer patients. J Can Res Ther 2017;13:257-61

How to cite this URL:
Haghi AR, Vahedi A, Shekarchi AA, Kamran A. Correlation of serum intercellular adhesion molecule 1 and vascular endothelial growth factor with tumor grading and staging in breast cancer patients. J Can Res Ther [serial online] 2017 [cited 2019 Nov 15];13:257-61. Available from: http://www.cancerjournal.net/text.asp?2017/13/2/257/204894

This article is being retracted due to author conflict and breach of ethics.








 

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