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BRIEF COMMUNICATION
Year : 2017  |  Volume : 13  |  Issue : 1  |  Page : 137-138

Role of aquaporins in oral cancer


Department of Oral Pathology and Microbiology, Dr. D. Y. Patil University's, Dr. D. Y. Patil Dental College and Hospital, Pune, Maharashtra, India

Correspondence Address:
Mamatha G. S. Reddy
Department of Oral Pathology and Microbiology, Dr. D. Y. Patil University's, Dr. D. Y. Patil Dental College and Hospital, Pune - 411 018, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.204848

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Aquaporins (AQP) are the membrane proteins involved in the transport of water and some neutral solutes. Thirteen types of AQP are identified in various human tissues. The expression of AQP's has been studied in various tumors among one is oral cancer. These molecules are involved in cell proliferation, migration, and metastasis. AQP target inhibitors act directly or indirectly through focal adhesion kinase-mitogen-activated protein kinase signaling pathway and shown promising results along with anti-cancer drugs. However, further researches were required to verify the efficiency and safety of these AQPs-target inhibitors in clinical therapy.


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