Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 8  |  Page : 229-232

Helicobacter pylori infection and pancreatic cancer risk: A meta-analysis


Department of Clinical Laboratory, Beijing Jishuitan Hospital, Beijing, P.R. China

Correspondence Address:
Jun Wu
Department of Clinical Laboratory, Beijing Jishuitan Hospital, Beijing
P.R. China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.200744

Rights and Permissions

Objective: To assess whether the Helicobacter pylori (HP) infection can increase the risk of developing pancreatic cancer or not by meta-analysis. Methods: Published studies about HP infection and pancreatic cancer risk were electronic searched in the databases of MEDLINE, PubMed, Web of Science, and CNKI. The correlation between HP infection and pancreatic cancer was demonstrated by odds ratio (OR) and corresponding 95% confidence interval (CI). The publication bias was assessed by Begg's funnel plot and Egger's linear regression test. Results: We finally included eight case–control studies for this present meta-analysis with 1003 pancreatic cancer patients and 1754 healthy controls. One study performed in Austria, 3 from China, and 4 from the United States. For obvious statistical heterogeneity, the data were pooled by random effects model. The pooled data indicated that significant correlation between HP infection and pancreatic cancer was found with OR = 1.45 (95% CI = 1.09–1.92) under the random effects model. The results indicated that the HP infection can significantly increase the risk of developing pancreatic cancer. The publication bias was evaluated by Begg's funnel plot and Egger's linear regression test. The Begg's funnel plot was significant asymmetric at the bottom which indicated potential publication bias. The Egger's linear regression test also indicated significant publication bias (t = 3.21, P < 0.05). Conclusion: Based on present open published data, HP infection can significantly increase the risk of developing pancreatic cancer. However, for small number of studies included in this meta-analysis and publication bias, more case–control or cohort studies are needed to further confirm this conclusion.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1245    
    Printed40    
    Emailed0    
    PDF Downloaded221    
    Comments [Add]    

Recommend this journal