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Year : 2016  |  Volume : 12  |  Issue : 2  |  Page : 699-704

rs61764370 polymorphism of Kras and risk of cancer in Caucasian population: A meta-analysis

Department of Clinical Laboratory, Affiliated Fuding Hospital, Fujian University of Traditional Medicine, Fuding, Fujian, China

Correspondence Address:
Shi-Yan Zhang
Department of Clinical Laboratory, Fuding Hospital, Fujian University of Traditional Medicine, 120 South Road of Old City, Fuding
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.147379

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Background: Kras is an important oncogene that plays a pivotal role in carcinogenesis. Rs61764370 polymorphism in Kras 3'-untranslated region is a candidate factor for contributing susceptibility to cancer. However, the results of emerging studies concerning association between rs61764370 and cancer risk remain elusive. Materials and Methods: The association between rs61764370 and risk of cancer was evaluated in 30 studies including 14936. cases and 15168 controls. Results: Meta-analysis result showed that genotype. GT/GG of rs61764370 was not associated with cancer in Caucasian population. After stratifying the overall population into cancer type subgroups, no significant association was observed between genotype. GT/GG and ovarian, breast, colorectal, non.-small cell lung cancer or head-neck carcinoma in Caucasian population, respectively. Conclusion: These results indicated that genotype. GT/GG of rs61764370 was not a genetic susceptible risk factor for cancer, and rs61764370 could not be used as a biomarker for estimating cancer risk in Caucasian population.

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