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ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 2  |  Page : 676-680

Meta-analysis of the relationship between microRNA-499 rs3746444 polymorphism and hepatocellular carcinoma risk in Asians


1 Department of Radiology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China
2 Department of Hepatic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China

Correspondence Address:
Jinliang Ma
Department of Hepatic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, 17 LuJiang Road, Hefei 230001
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.154002

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Objective: Numerous studies have reported the role of microRNA-499 rs3746444 polymorphism with hepatocellular carcinoma. (HCC) risk in Asians, but the specific association is still controversial. Materials and Methods: To derive a more precise estimation of the relationship, a meta-analysis was performed. An electronic search of PubMed database was conducted to select relevant studies. Odds ratios. (ORs) with 95% confidence intervals. (CIs) were estimated to assess the relationship between microRNA-499 rs3746444 polymorphism and HCC risk in Asians. Results: Eight relevant studies including 2196 cases and 2701 controls were included in this meta-analysis. When all the eligible studies were pooled into this meta-analysis, no significant association of HCC risk with microRNA-499 rs3746444 polymorphism was found in Asians (TT vs. CC: OR = 1.00 95% CI = 0.54–1.83; TT vs. TC: OR = 0.89, 95% CI = 0.66–1.20; dominant model: OR = 1.13, 95% CI = 0.81–1.58; recessive model: OR = 0.99, 95% CI = 0.56–1.76). Conclusion: This meta-analysis suggests that the microRNA-499 rs3746444 polymorphism is not contributed to the risk of HCC in Asians. However, more studies should be performed in the future to confirm this association.


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