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ORIGINAL ARTICLE
Year : 2016  |  Volume : 12  |  Issue : 2  |  Page : 543-549

Association between fibroblast growth factor receptor-2 gene polymorphism and risk of breast cancer in Chinese populations: A HuGE review and meta-analysis


1 Department of Pathology, Health Science Center, Hebei University, Baoding, People's Republic of China
2 Library, Hebei University, Baoding, People's Republic of China
3 Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding, People's Republic of China

Correspondence Address:
Wei-Ming Wang
Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, No. 212 Yuhuadonglu, Baoding-071 000
People's Republic of China
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Source of Support: This work was supported by the grants from the Hebei University, Administration of Traditional Chinese Medicine of Hebei Province, Research Center for Eco-Environmental Sciences of the Chinese Academy of Sciences (Nos. 2012A1002, 2011213, KF2010-17, 2011107, and 2008071), and the Departments of Science and Technology of Baoding city and Hebei Province(Nos.13ZF019 and 132777163), and Natural Science Foundation of Hebei Province, China (grant: H2012201136)., Conflict of Interest: None


DOI: 10.4103/0973-1482.148715

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Aim of study: To evaluate the effect of fibroblast growth factor receptor.2. (FGFR2) on genetic susceptibility for breast cancer. (BC) in Chinese populations. Materials and Methods: A computerized literature search was carried out in PubMed, Chinese Biomedical Database. (CBM), and Chinese National Knowledge Infrastructure. (CNKI) to collect relevant articles. Pooled odds ratio. (OR) and 95% confidence interval. (CI) were used to assess the strength of the associations. Results: A total of 21 articles involving a total of 15 polymorphisms of the FGFR2 gene were included in the meta-analysis. Due to the limited studies for rs17102287, rs2981578, rs3135718, rs3803662, rs3750817, rsl0510097, rsl7542768, rs13387042, and rs1982073; we only pooled the six polymorphisms. (rs11200014, rs1219648, rs2420946, rs2912778, rs2981579, and rs2981582) into this meta.analysis. Overall, significantly increased BC risk was associated with five polymorphisms. (rs2981579, rs2981582, rs1219648, rs2420946, and rs2912778) when all studies were pooled into the meta.analysis. When stratified by ethnicity and source of controls, similar results were also detected. However, for rs2981579 no significant association was found among Chinese Han in all genetic models. Conclusion: Our meta-analysis suggests that FGFR2 is likely an important genetic marker contributing to susceptibility of BC. We recommend that these single nucleotide polymorphisms to be included in future association studies and functional assays.


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