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Year : 2016  |  Volume : 12  |  Issue : 2  |  Page : 464-468

Anesthetics impact on cancer recurrence: What do we know?

1 Department of Anesthesiology, Dr. BRAIRCH, All India Institute of Medical Sciences, New Delhi, India
2 Department of Anesthesiology and Perioperative Medicine, University of Manitoba, Winnipeg, Canada
3 Department of Anesthesiology and Neurological Surgery, Wexner Medical Center, Ohio State University, Columbus, Ohio, USA
4 Department of Anaesthesiology and Intensive Therapy, University of Pecs, Pecs, Hungary

Correspondence Address:
Tumul Chowdhury
Department of Anesthesiology and Perioperative Medicine Health Sciences Center, University of Manitoba, 2nd Floor, Harry Medovy House, 671 - William's Ave., Winnipeg, R3E 0Z2
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.148670

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Surgery is an important component of treatment in cancer patients. However, surgical stress, anesthesia, and perioperative analgesia interfere with the host immune defense mechanisms and may contribute to metastatic dissemination of malignant tumors and cancer progression. Little is known about the effects of anesthesia on tumor recurrence. In vivo studies and clinical data show some evidence that regional anesthesia is beneficial for cancer patients as it may decrease the risk of metastasis. This short review summarizes the clinical data on the possible association between anesthesia, perioperative analgesia, and the risk of cancer recurrence. Most of the clinical reports are based on retrospective studies, and properly designed prospective trials including a sufficient number of patients is required to reveal the interaction of various anesthetic drugs and methods and cancer progression.

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