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ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 5  |  Page : 112-114

A meta-analysis of comprehensive care on quality of life in patients with lung cancer


Department of Emergency, Huaihe Hospital of Henan University, Henan, Kaifeng 475000, China

Date of Web Publication31-Aug-2015

Correspondence Address:
Dr. Xiang Wang
Department of Emergency, Huaihe Hospital of Henan University, Henan, Kaifeng 475000
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.163860

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 > Abstract 

Objective: The aim of this meta-analysis was to evaluate the efficacy of comprehensive care on quality of life in patients with lung cancer.
Methods: The clinical studies about comprehensive care on quality of life in patients with lung cancer were searched in the Medline, PubMed, EMBASE, CNKI, and WANFANG databases. The score of society function, emotional function, somatic function, cognitive function was collected in each of the included studies. And the data were pooled by Stata version 11.0 software.
Result: Finally, three clinical studies including 536 cases were included in this meta-analysis. Significant statistical heterogeneity was existed in the three papers (P < 0.05). The data were pooled by random effect model. The combined results showed that the quality of life for lung cancer patients can be significantly improved in the aspects of society function (standardized mean difference [SMD] =0.41, 95% confidence interval [CI]: 0.10-0.71), emotional function (SMD = 0.45, 0.12-0.78), somatic function (SMD = 0.98, 95% CI: 0.51-1.44), and cognitive function (SMD = 0.64, 95% CI: 0.44-0.83).
Conclusion: Quality of life for lung cancer patients can be significantly improved through comprehensive care.

Keywords: Comprehensive care, lung cancer, meta-analysis, quality of life


How to cite this article:
Wang X, Cao H. A meta-analysis of comprehensive care on quality of life in patients with lung cancer. J Can Res Ther 2015;11, Suppl S1:112-4

How to cite this URL:
Wang X, Cao H. A meta-analysis of comprehensive care on quality of life in patients with lung cancer. J Can Res Ther [serial online] 2015 [cited 2019 Oct 20];11:112-4. Available from: http://www.cancerjournal.net/text.asp?2015/11/5/112/163860

Xiang Wang and Haili Cao contribute equally to this work.



 > Introduction Top


Primary malignant lung carcinoma is currently the leading cause of cancer-related mortality worldwide. [1],[2] With the rising incidence of lung cancer, the researches related to lung cancer attract more and more attentions. Nonsmall cell lung cancer accounts for a high proportion in lung cancer. During the past decades, great progress has been made for the diagnosis and treatment of lung cancer. It is estimated that about 384,000 survivors of lung cancers, accounting for 4% of the US population of adult cancer survivors. [3],[4],[5] However, little attention has been given to these lung cancer survivors. [6] Several articles have reported that the comprehensive care can improve the quality of life for lung cancer patients. [7] Here, we performed a meta-analysis according to the published articles to further evaluate the efficacy of comprehensive care for life quality improving.


 > Methods Top


The clinical studies about comprehensive nursing on the quality of life in patients with lung cancer were searched in the Medline, PubMed, EMBASE, CNKI, and WANFANG databases. The score of society function, emotional function, somatic function, cognitive function was collected in each of the included studies. The first author and corresponding author name, year of paper publication, and country were also extracted by two reviewers (Wang Xiang, Cao Haijing).

Statistics

All of the data were analyzed by the statistical software Stata version 11.0 (Stata Corporation, College Station, TX, USA). The results of continuous data were reported as MD with 95% CI. P < 0.05 was considered to indicate a statistically significant difference. [8]


 > Results Top


Characteristics of included papers

Through searching the Medline, PubMed, EMBASE, CNKI, and WANFANG databases, we finally find and included three articles reporting the comprehensive care on quality of life in patients with lung cancer. The general characteristics are shown in [Table 1].
Table 1: The main information for the included 3 papers


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Synthesis of outcomes and assessments of heterogeneity

Significant statistical heterogeneity was existed in the three papers (P < 0.05). The data were pooled by random effect model. The combined results showed that the quality of life for lung cancer patients can be significantly improved in the aspects of society function (standardized mean difference [SMD] =0.41, 95% confidence interval [CI]: 0.10-0.71), emotional function (SMD = 0.45, 0.12-0.78), somatic function (SMD = 0.98, 95% CI: 0.51-1.44), and cognitive function (SMD = 0.64, 95% CI: 0.44-0.83) [Figure 1].
Figure 1: Forest plot of comprehensive care on quality of life in patients with lung cancer

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Publication bias

The funnel plot was asymmetric which indicates significant publication bias was existed in this meta-analysis [Figure 2].
Figure 2: Funnel plot of comprehensive care on quality of life in patients with lung cancer

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 > Discussion Top


In this meta-analysis, we finally included three clinical studies with 536 cases. The combined results showed that the quality of life for lung cancer patients can be significantly improved in the aspects of society function (SMD = 0.41, 95% CI: 0.10-0.71), emotional function (SMD = 0.45, 0.12-0.78), somatic function (SMD = 0.98, 95% CI: 0.51-1.44), and cognitive function (SMD = 0.64,95%CI: 0.44-0.83). Quality of life for lung cancer patients can be significantly improved through comprehensive care.

Quality improving for lung cancer patients is very important especially for no-curable patients. [11],[12],[13] In this study, we found giving the comprehensive care under the basic nursing can significantly improve the patient's health condition. By creating a good environment for the patient and the humane environment (such as encouraging the exchange of patients with family and friends), the society function and emotional function were significantly improved for the lung cancer patients. The emotional and cognitive functions are related to the psychological status of the patients. Moreover, it varied a lot because of patient's individual social demographic characteristics, disease, and treatment. Therefore, comprehensive nursing intervention by certain effect, suggesting that in the implementation of interventions in the process should pay attention to the patient's individual differences and individual measurements. [14],[15]

This meta-analysis indicated that the quality of life for lung cancer patients can be significantly improved through comprehensive care. But for only three studies and a small number of patients included, the result was not stable. Therefore, multicenter prospective clinical randomized controlled trials were needed for further evaluation with the efficacy of comprehensive care for lung cancer patient's life quality improvement.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
 > References Top

1.
Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29.  Back to cited text no. 1
    
2.
Zheng R, Zeng H, Zhang S, Fan Y, Qiao Y, Zhou Q, et al. Lung cancer incidence and mortality in China, 2010. Thorac Cancer 2014;5:330-6.  Back to cited text no. 2
    
3.
Jemal A, Thun MJ, Ries LA, Howe HL, Weir HK, Center MM, et al. Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control. J Natl Cancer Inst 2008;100:1672-94.  Back to cited text no. 3
    
4.
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62:10-29.  Back to cited text no. 4
    
5.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.  Back to cited text no. 5
    
6.
Furman MJ, Lambert LA, Sullivan ME, Whalen GF. Rational follow-up after curative cancer resection. J Clin Oncol 2013;31:1130-3.  Back to cited text no. 6
    
7.
Lina Y, Yaping Y. Influence of nursing intervention on quality of life of patients with lung cancer. J North Pharm 2012;9:116-7.  Back to cited text no. 7
    
8.
Tian DY, Tian J, Shi CH, Song B, Wu J, Ji Y, et al. Calcium intake and the risk of stroke: An up-dated meta-analysis of prospective studies. Asia Pac J Clin Nutr 2015;24:245-52.  Back to cited text no. 8
    
9.
Rongxiang X. Influence of nursing intervention on quality of life of patients with lung cancer. J Qilu Nurs 2011;12:33-4.  Back to cited text no. 9
    
10.
Min L, Aifang X, Yuanling M. Effect of psychological intervention on quality of life of patients with lung cancer chemotherapy. Today Nurse 2009;16:5-6.  Back to cited text no. 10
    
11.
Zoganas L, Bablekos G, Maiwand M, Charalabopoulos A, Andronadi V, Batistatou A, et al. Quality of life survey and palliative care in lung cancer patients. Hippokratia 2006;10:163-6.  Back to cited text no. 11
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12.
Brown J, Thorpe H, Napp V, Fairlamb DJ, Gower NH, Milroy R, et al. Assessment of quality of life in the supportive care setting of the big lung trial in non-small-cell lung cancer. J Clin Oncol 2005;23:7417-27.  Back to cited text no. 12
    
13.
Spiro SG, Rudd RM, Souhami RL, Brown J, Fairlamb DJ, Gower NH, et al. Chemotherapy versus supportive care in advanced non-small cell lung cancer: Improved survival without detriment to quality of life. Thorax 2004;59:828-36.  Back to cited text no. 13
    
14.
Huang J, Logue AE, Ostroff JS, Park BJ, McCabe M, Jones DR, et al. Comprehensive long-term care of patients with lung cancer: Development of a novel thoracic survivorship program. Ann Thorac Surg 2014;98:955-61.  Back to cited text no. 14
    
15.
Üstündag S, Zencirci AD. Factors affecting the quality of life of cancer patients undergoing chemotherapy: A questionnaire study. Asia Pac J Oncol Nurs 2015;2:17-25.  Back to cited text no. 15
    


    Figures

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    Tables

  [Table 1]



 

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