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Year : 2015  |  Volume : 11  |  Issue : 4  |  Page : 1042

Micronuclei in breast aspirates

1 Medical Center, Shantou, China
2 Hainan Medical University, Haikou, China

Date of Web Publication15-Feb-2016

Correspondence Address:
Sim Sai Tin
Medical Center, Shantou
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.146138

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How to cite this article:
Tin SS, Wiwanitkit V. Micronuclei in breast aspirates. J Can Res Ther 2015;11:1042

How to cite this URL:
Tin SS, Wiwanitkit V. Micronuclei in breast aspirates. J Can Res Ther [serial online] 2015 [cited 2020 Aug 3];11:1042. Available from: http://www.cancerjournal.net/text.asp?2015/11/4/1042/146138


We would like to discuss on the report on “micronuclei in breast aspirates”.[1] Hemalatha et al. concluded “micronuclei scoring can be used as a biomarker on fine-needle aspiration cytology smears of breast carcinoma”.[1] There are some concerns on the scoring system. First, as a cytological investigation, it requires experienced cytologist for scoring.[2] In addition, the problem on interobserver variation can be expected.[3],[4],[5] Second, focusing on the result reported by Hemalatha et al.[1] that the scoring in malignant and nonmalignant lesions could be observed, there are some previous reports with discordant results. Samanta et al. noted that grade 1 ductal carcinoma had the same score as fibroadenoma, and this can be a problem in diagnosis.[6]

 > References Top

Hemalatha A, Suresh TN, HarendraKumar ML. Micronuclei in breast aspirates. Is scoring them helpful? J Cancer Res Ther 2014;10:309-11.  Back to cited text no. 1
Fenech M. The micronucleus assay determination of chromosomal level DNA damage. Methods Mol Biol 2008;410:185-216.  Back to cited text no. 2
Dertinger SD, Bishop ME, McNamee JP, Hayashi M, Suzuki T, Asano N, et al. Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring. Toxicol Sci 2006;94:83-91.  Back to cited text no. 3
Patino-Garcia B, Hoegel J, Varga D, Hoehne M, Michel I, Jainta S, et al. Scoring variability of micronuclei in binucleated human lymphocytes in a case-control study. Mutagenesis 2006;21:191-7.  Back to cited text no. 4
Fenech M, Bonassi S, Turner J, Lando C, Ceppi M, Chang WP, et al. Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project. Mutat Res 2003;534:45-64.  Back to cited text no. 5
Samanta S, Dey P, Nijhawan R. The role of micronucleus scoring in fine needle aspirates of ductal carcinoma of the breast. Cytopathology 2011;22:111-4.  Back to cited text no. 6


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