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Year : 2015  |  Volume : 11  |  Issue : 3  |  Page : 663

Clinicopathological analysis of two cases with pelvis villous adenoma and review of relevant literature

Department of Pathology, The First People Hospital of Wenling, Wenling, 317500, China

Date of Web Publication9-Oct-2015

Correspondence Address:
Guorong Chen
Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.144653

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 > Abstract 

Villous adenoma is a rare primary tumor of the urinary system, especially the bladder and kidneys. This study presents two cases of right pelvis villous adenoma, including that of a 61-year-old patient who had experienced hematuria for more than 1 year and was diagnosed with bladder and ureteral stones via B-ultrasound examination, and the other one involving a 65-year-old patient who was hospitalized for 6 days due to a right upper quadrant mass and diagnosed with right renal pelvis stones and hydrops via B-ultrasound examination. Both patients underwent nephrectomy, and their histological analysis demonstrated papillary projections covered by columnar cells and goblet cells. The first patient had a large amount of renal pelvis mucus accumulation with obvious microscopic intestinal metaplasia and mild-moderate nuclear atypia. Immunohistochemical studies revealed positive carcinoembryonic antigen and the caudal type homeobox 2 staining with varying degrees of cytokeratin (CK)-7 and CK20 expression in both patients. Recurrences or metastasis was not observed during the follow-up period of 3-4 years.

Keywords: Clinical pathology, immunohistochemistry, prognosis, renal pelvis villous adenoma

How to cite this article:
Dong C, Yang Y, Wu S, Chen G. Clinicopathological analysis of two cases with pelvis villous adenoma and review of relevant literature. J Can Res Ther 2015;11:663

How to cite this URL:
Dong C, Yang Y, Wu S, Chen G. Clinicopathological analysis of two cases with pelvis villous adenoma and review of relevant literature. J Can Res Ther [serial online] 2015 [cited 2020 May 28];11:663. Available from: http://www.cancerjournal.net/text.asp?2015/11/3/663/144653

 > Introduction Top

Tuberculosis (TB) is a common infection with approximately one-third of the world's population. Genitourinary TB is rare, but its incidence has increased in human immunodeficiency virus (HIV)-infected patients and those using immunosuppressant agents. [1] Granulomatous prostatitis is an uncommon inflammation of the prostate and mimics prostatic adenocarcinoma. 18 F-flouro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is a preferred modality for real time assessment of the activity of TB, because FDG accumulates in inflammatory cells such as neutrophils and activated macrophages at the site of inflammation. [2] It was presented that FDG-PET/CT was significantly more efficient when compared with CT, respectively, in over half of patients for the identification of sites of lymph node involvement that were missed by CT and often the only sites of extrapulmonary TB identified. [3] But availability of FDG-PET/CT for differential diagnosis of malignant lymph node involvement from lymph node involvement by TB is not enough for routine practice. [3]

The authors report herein a case of simultaneous prostate and lung TB presenting as hypermetabolic lesions in the prostate and lung on FDG-PET/CT, in an immunocompetent patient. This is the first case presenting with lesions in the prostate and lung.

 > Case report Top

A 65-year-old heterosexual, married, Caucasian male patient was seen in the outpatient department with a 1-month history of cough, sputum production, malaise, weight loss, and night sweats. His family history was significant for lung cancer in his father and brother; however, none of the members of his family had evidence of TB. Clinical examination was unremarkable. Laboratory data were within normal limits, and HIV testing was negative. Three separate sputum samples were negative for acid-fast bacilli. Chest X-ray showed a right upper lobe heterogeneous infiltration. Contrast-enhanced chest CT showed a dense lesion, in the anterior apical zone of upper right lobe measuring approximately 36.5 mm × 21.5 mm. Pleural thickening to 14 mm was observed adjacent to the lesion. No mediastinal adenopathy or other significant abnormality was detected. The patient then underwent FDG-PET/CT using a Siemens Biograph Duo (Siemens CTI, Knoxville, Tennessee). The maximum standardized uptake value (SUV) of the mass in the posterior segment of right upper lobe measuring 4 cm × 2 cm was 1.9 [Figure 1]. There were no mediastinal lymph nodes detected; however, on the posterior of this mass, PET revealed a high accumulation of FDG in another mass with a maximum SUV of 3.9 during the early phase and 5 during the late phase. This metabolic behavior was consistent with carcinoma according to the nuclear medicine report, and associated with thickening of pleura adjacent to the mass. Incidentally, FDG-PET/CT demonstrated two areas of high-intensity FDG uptake of varying size within the prostate, with maximum SUV of 8.9 [Figure 1].
Figure 1: Histomorphology. (a) The first patient had villous epithelial cells covered with overlapping, crowded nipple cells moving from the upper of the base to the middle, mild to moderate dysplasia mixed with goblet cells (H and E, medium times). (b) The second case had fluffy nipple consisted of simple columnar mucous cells, nucleus located at the base and no obvious atypical interspersed goblet cells (H and E, medium times)

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The patient reported hesitancy, incomplete evacuation, urgency and intermittency. On digital rectal examination (DRE), the prostate was found to be hard and nodular. The patient's serum total prostate specific antigen (PSA) level was elevated at 5.4 ng/ml. Routine urine examinations and culture were normal. Transrectal ultrasound (TRUS) examination and biopsy were performed with a Sonoline Elegra Ultrasonograph (Siemens Ultrasound Division, Mountain View, CA) equipped with a 6.5-MHz endorectal probe. TRUS showed increased prostate volume and a diffuse hypoechoic lesion within the peripheral region of the left prostatic lobe deforming the capsule that was thought to be a tumor. TRUS guided biopsy of prostate (TRUS-Bx) was performed. In addition to 12 standard systematic TRUS-Bx, the diffuse hypoechoic lesions were specifically targeted. Pathology revealed a granulomatous inflammation with multiple caseous epithelioid granulomas containing Langhans' and foreign-body type giant cells and central amorphous, eosinophilic necrotic material [Figure 2].

The patient was diagnosed with prostatic TB and treated with isoniazid, rifampicin, pyrazinamide and ethambutol daily for 2 months with isoniazid and rifampicin continued for an additional 6 months. Clinical findings resolved within 2 months after treatment. He did not experience any side-effects from the treatment. Six months later, the DRE revealed that prostate gland had become soft and was decreased in size and the chest X-ray showed no abnormalities.
Figure 2: Immunohistochemical phenotype. (a) Positive cytokeratin (CK) 20 tumor cell cytoplasm (CK20 staining, medium times) (b) positive caudal type homeobox 2 (CDX2) tumor nuclei (CDX2, medium times)

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 > Discussion Top

In 2010, there were 8.8 million incident cases of TB, 1.1 million deaths from TB among HIV-negative. After infection of the lung, Mycobacterium TB bacilli are carried to the regional lymph nodes and may be delivered to the venous system from the thoracic duct, resulting in hematogenous seeding of genitourinary tract. Prostatic TB has also been reported in HIV positive patients; however, this patient had a negative HIV test during workup.

Male genital TB is still a diagnostic and therapeutic challenge, because of its rarity. It was reportedly seen in <0.5% of all patients with extrapulmonary TB and 15% of all patients with pulmonary TB. [4] Involvement of prostate is usually secondary to infection from the upper urinary and genital tract through direct intracanalicular extension or hematogenous spread. Additionally, some cases have been linked to the use of BCG vaccine for superficial bladder cancer. [5] Lee et al. reported that half of prostatic TB is associated with TB of epididymis; however, in the patient presented here, the kidneys and genital organs were normal and the patient had no symptoms associated with upper genitourinary tract.

The clinical symptoms of prostatic TB are usually nonspecific. Common symptoms include frequency and nocturia. The patient in this presentation did have some obstructive symptoms that were previously thought to be due to benign prostatic hypertrophy. DRE findings in prostatic TB are similar to those in prostate cancer and typically include hard, non-tender nodules. TRUS presents enlargement of the gland and solitary or diffuse hypoechoic lesions of varying sizes within the peripheral zone. Tuberculous prostatitis is not easily differentiated from adenocarcinoma with PSA levels as some patients, such as the one presented here, may have elevated PSA. Urinalysis frequently shows hematuria and/or sterile pyruia, but may be normal, as in this case. [5]

Urine acid fast bacillus stain or culture is frequently positive in cases of upper genitourinary TB, but evaluation of ejaculate and prostatic secretions is often necessary to diagnose prostatic disease. It was diagnosed incidentally by the pathologist after a transurethral resection or prostate biopsy. The histopathological examination of the prostate biopsy in this case revealed Langhans cells and caseous necrosis, which led to the diagnosis.

There are several studies on TB lesions showing FDG uptake mimicking malignancy. [6],[7] Therefore FDG-PET/CT cannot be used to differentiate between malignancies and TB, because it is extremely difficult to distinguish malignancies from TB only by FDG uptake. [8] It was suggested that in some patients, dual-phase FDG-PET/CT may be useful to determine whether a site of pulmonary up take of FDG is malignant or benign. [8] But the washout rates or retention indexes of FDG measured by change in maximum SUV cannot be helpful in differentiating TB from cancer. [2] Shinohara et al. reported FDG-PET/CT findings in a case of primary tuberculous pleurisy presenting with pleural thickening without parenchymal lung lesions mimicking malignant mesothelioma. [9] Moreover, several case reports demonstrated FDG uptake in abdominal TB lesions mimicking peritoneal carcinomatosis. [10] A report documented tuberculous lesions in the epididymis and prostate found incidentally on follow-up PET for lymphoma. [11] In our case the intense FDG uptake in lung and prostate was initially interpreted as the prostatic carcinoma and its metastasis to the lung.

The combination of isoniazid, rifampicin and pyrazinamide, and ethambutol is first choice of pharmacological treatment. Many cases, like the one presented here, will respond to antibiotics alone, but genitourinary TB frequently requires surgery to cure. [11]

 > Conclusion Top

Prostatic TB can show high focal FDG uptake on PET/CT, which is often difficult to distinguish from malignancy such as prostatic adenocarcinoma.

 > References Top

Yoon HJ, Song YG, Park WI, Choi JP, Chang KH, Kim JM. Clinical manifestations and diagnosis of extrapulmonary tuberculosis. Yonsei Med J 2004;45:453-61.  Back to cited text no. 1
Sathekge M, Maes A, Van de Wiele C. FDG-PET imaging in HIV infection and tuberculosis. Semin Nucl Med 2013;43:349-66.  Back to cited text no. 2
Sathekge M, Maes A, D′Asseler Y, Vorster M, Van de Wiele C. Nuclear medicine imaging in tuberculosis using commercially available radiopharmaceuticals. Nucl Med Commun 2012;33:581-90.  Back to cited text no. 3
Jacob JT, Nguyen TM, Ray SM. Male genital tuberculosis. Lancet Infect Dis 2008;8:335-42.  Back to cited text no. 4
Kulchavenya E, Kim CS, Bulanova O, Zhukova I. Male genital tuberculosis: Epidemiology and diagnostic. World J Urol 2012;30:15-21.  Back to cited text no. 5
Chen CJ, Yao WJ, Chou CY, Chiu NT, Lee BF, Wu PS. Peritoneal tuberculosis with elevated serum CA125 mimicking peritoneal carcinomatosis on F-18 FDG-PET/CT. Ann Nucl Med 2008;22:525-7.  Back to cited text no. 6
Wang YT, Lu F, Zhu F, Qian ZB, Xu YP, Meng T. Primary hepatic tuberculoma appears similar to hepatic malignancy on F-18 FDG PET/CT. Clin Nucl Med 2009;34:528-9.  Back to cited text no. 7
Ito K, Morooka M, Minamimoto R, Miyata Y, Okasaki M, Kubota K. Imaging spectrum and pitfalls of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with tuberculosis. Jpn J Radiol 2013;31:511-20.  Back to cited text no. 8
Shinohara T, Shiota N, Kume M, Hamada N, Naruse K, Ogushi F. Asymptomatic primary tuberculous pleurisy with intense 18-fluorodeoxyglucose uptake mimicking malignant mesothelioma. BMC Infect Dis 2013;13:12.  Back to cited text no. 9
Takalkar AM, Bruno GL, Reddy M, Lilien DL. Intense FDG activity in peritoneal tuberculosis mimics peritoneal carcinomatosis. Clin Nucl Med 2007;32:244-6.  Back to cited text no. 10
Lee G, Lee JH, Park SG. F-18 FDG PET/CT imaging of solitary genital tuberculosis mimicking recurrent lymphoma. Clin Nucl Med 2011;36:315-6.  Back to cited text no. 11


  [Figure 1], [Figure 2]


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