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E-JCRT CORRESPONDENCE
Year : 2015  |  Volume : 11  |  Issue : 3  |  Page : 656

A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult


1 Department of Pathology, Kasturba Medical College, Mangalore, Manipal University, Manipal, India
2 Department of Pathology, Yenepoya Medical College, Yenepoya University, Mangalore, India
3 Department of Surgery, Yenepoya Medical College, Yenepoya University, Mangalore, India
4 Department of Pathology, Surgical Pathologist and Immunochemist, Lab Surgpath, The Human Protien Atlas (HPA) Project, Mumbai, Maharashtra, India

Correspondence Address:
H B Sridevi
Department of Pathology, Kasturba Medical College, Mangalore, Manipal University, Manipal - 575 001, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.139338

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Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained.


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