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E-JCRT CORRESPONDENCE
Year : 2015  |  Volume : 11  |  Issue : 3  |  Page : 654

Variant Philadelphia translocations in chronic myeloid leukemia: A report of five cases


1 Department of Pathology, MS Ramaiah Medical College and Hospital, Bangalore, Karnataka, India
2 Department of Medical Oncology, MS Ramaiah Medical College and Hospital, Bangalore, Karnataka, India
3 Department of Cytogenetics, MS Ramaiah Medical College and Hospital, Bangalore, Karnataka, India

Correspondence Address:
Vijaya V Mysorekar
89, AG's Office Colony, 5th Main, 6th Cross, New BEL Road, Bangalore - 560 054, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.138036

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The t (9;22)(q34;q11) translocation is found in about 90% of the chronic myeloid leukemia patients. About 5 - 10% of these patients have complex variant translocations involving a third chromosome in addition to chromosomes 9 and 22. We describe five male patients in the chronic myeloid leukemia-chronic phase, with rare variant Philadelphia translocations. All of them had the BCR-ABL fusion gene and responded well to treatment with imatinib mesylate. All the patients are on regular follow-up.


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