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Year : 2015  |  Volume : 11  |  Issue : 3  |  Page : 646

Extensive osteolytic skull base amyloidoma simulating malignancy: A rare pseudotumor producing a diagnostic dilemma

1 Department of Pathology, Govind Ballabh Pant Hospital, New Delhi, India
2 Department of Radiodiagnosis, Govind Ballabh Pant Hospital, New Delhi, India
3 Department of Neurosurgery, Govind Ballabh Pant Hospital, New Delhi, India

Correspondence Address:
Vineeta V Batra
Department of Pathology, Academic Block, Govind Ballabh Pant Hospital, Jawaharlal Nehru Marg, New Delhi - 110002
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.137999

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Although amyloidomas are quite well-known, intracranial, and especially skull base lesions have been rarely reported. Extensive lesions in the skull base frequently simulate malignancy clinicoradiologically. Diagnosis of these lesions is important as they offer a favorable prognosis. We describe a large infiltrating osteolytic skull base tumor-like lesion in a 45-year-old male without evidence of associated plasma cell dyscrasia. Squash smears and histopathology revealed a plasma cell-rich lesion with abundant amyloid, confirming amyloidoma. To conclude, amyloidoma of the skull base is a rare tumor-like lesion, with timely diagnosis and management offering a good prognosis.

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