Combination of retrograde superselective intra-arterial chemotherapy and Seldinger method in locally advanced oral cancer
Masataka Uehara1, Ryouichi Ohya2, Masaaki Kodama1, Takeshi Shiraishi3, Izumi Asahina3, Kazuhiro Tominaga1
1 Department of Science of Physical Functions, Division of Maxillofacial Surgery, Kyushu Dental University, Kitakyushu, Fukuoka, Japan
2 Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
3 Department Regenerative Oral Surgery, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Department of Science of Physical Functions, Division of Maxillofacial Surgery, Kyushu Dental University, 2-6-1, Manazuru, Kokurakita-ku, Kitakyushu 803 8580, Fukuoka
Source of Support: None, Conflict of Interest: None
The nonsurgical strategies for locally advanced oral cancer are desirable. Superselective intra-arterial infusion with radiotherapy was utilized for this purpose, and there are two types of superselective intra-arterial infusion methods: The Seldinger method and the retrograde superselective intra-arterial chemotherapy (HFT method). In one case, the HFT method was applied to locally advanced tongue cancer, and the Seldinger method was used for additional administration of cisplatin (CDDP) to compensate for a lack of drug flow in the HFT method. In another case, the HFT method was applied to locally advanced lower gingival cancer. The Seldinger method was applied to metastatic lymph nodes. In both cases, additional administration of CDDP using the Seldinger method resulted in a complete response. The combination of the HFT and Seldinger methods was useful to eradicate locally advanced oral cancer because each method compensated for the defects of the other.