Genetic variants identified by GWAS was associated with colorectal cancer in the Han Chinese population
Hui-Ping Qiao1, Chun-Yang Zhang2, Zhi-Long Yu3, Qi-Min Li2, Yang Jiao4, Jian-Ping Cao4
1 Department of Radio oncology, The First Affiliated Hospital of Baotou Medical College, Baotou; Department of Radiology, Medical College of Soochow University, Suzhou, Jiangsu, China
2 Department of Radio oncology, The First Affiliated Hospital of Baotou Medical College, Baotou, China
3 Department of Medicine and Therapeutics, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China
4 Department of Radiology, Medical College of Soochow University, Suzhou, Jiangsu, China
School of Radiation Medicine and Protection, Medical College, Soochow University 199 Renai Road, Suzhou Industrial Park, Suzhou (215123), Jiangsu
Source of Support: None, Conflict of Interest: None
Aim of Study: Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. Recently, genome-wide association studies have identified two single nucleotide polymorphisms (SNP) associated with CRC in Caucasians.
Materials and Methods: To validate whether the same variations conferred risk to CRC in the Han Chinese population, we genotyped 760 individuals (380 controls and 380 cases samples) recruited from the Han Chinese origin.
Results: We found rs11987193 in 8p12 (P = 0.0472 after correction, OR = 0.751) was significantly associated with CRC but rs12080929 in 1p33 (P = 0.0650 after correction, OR = 0.750) was not.
Conclusion: Our findings supported that rs11987193 is a susceptibility locus for CRC, and gene DUSP4 was possible to play a role in the pathology of CRC.