Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 2  |  Page : 438-442

Abnormal cerebral functional connectivity in esophageal cancer patients with theory of mind deficits in resting state


1 Department of Neurology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou 213003, China
2 Department of Radiology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou 213003, China
3 Department of Psychology, The Affiliated Zhongda Hospital of Southeast University, Nanjing 210000, China

Correspondence Address:
YongGui Yuan
Department of Psychology, The Affiliated Zhongda Hospital of Southeast University, No. 87 Hunan Road, Nanjing 210000
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.144594

Rights and Permissions

Objective: To explore the function of the default mode network (DMN) in the psychopathological mechanisms of theory of mind deficits in patients with an esophageal cancer concomitant with depression in resting the state. Subjects and Methods: Twenty-five cases of esophageal cancer with theory of mind deficits (test group) that meet the diagnostic criteria of esophageal cancer and neuropsychological tests, including Beck depression inventory, reading the mind in the eyes, and Faux pas, were included, Another 25 cases of esophageal cancer patients but without theory of mind deficits (control group) were enrolled. Each patient completed a resting-state functional magnetic resonance imaging. Results: The functional connectivity intensities within the cerebral regions in the DMN of all the enrolled patients were analyzed. The results of each group were compared. The functional connectivity of the bilateral prefrontal central region with the precuneus, bilateral posterior cingulate gyrus and bilateral ventral anterior cingulate gyrus in the patients of the test group were all reduced significantly (P < 0.05). In the resting state, the functional connectivity is abnormal in the cerebral regions in the DMN of esophageal cancer patients with theory of mind deficits. Conclusions: The theory of mind deficits might have an important function in the pathogenesis of esophageal cancer.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2139    
    Printed32    
    Emailed0    
    PDF Downloaded91    
    Comments [Add]    

Recommend this journal