Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 1  |  Page : 146-149

Status of trace elements in saliva of oral precancer and oral cancer patients


1 Department of Oral Medicine and Radiology, AB Shetty memorial Institute of Dental Science, Mangalore, Karnataka, India
2 Department of Biochemistry, KS Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India
3 Department of Oral Pathology, AB Shetty memorial Institute of Dental Science, Mangalore, Karnataka, India
4 Department of Oral Surgery, AB Shetty memorial Institute of Dental Science, Mangalore, Karnataka, India

Correspondence Address:
Shishir Ram Shetty
Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental, Sciences, Nitte University, Mangalore
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.137973

Rights and Permissions

Background: Several studies in recent years have linked association between micronutrient levels and various forms of cancer. Copper and zinc have been the most researched micronutrients. Aim: The aim of the study was to evaluate the levels of copper, zinc and iron in saliva of patients with oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. Results: There was a highly significant increase in the level of salivary copper in oral submucous fibrosis patients when compared to controls (P = 0.001). Salivary copper levels were also elevated in oral leukoplakia and oral cancer patients (P = 0.01). There was a significant decrease in the salivary zinc levels in all three study groups when compared to controls (P = 0.001). A highly significant reduction in salivary iron levels was noticed oral submucous fibrosis group. The copper to zinc ratio significantly increased in all the study groups when compared to controls. Conclusion: Results suggest that salivary copper zinc and iron could be used as biomarkers for oral precancer and cancer.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3578    
    Printed63    
    Emailed0    
    PDF Downloaded484    
    Comments [Add]    

Recommend this journal