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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 7  |  Page : 222-224

A meta-analysis of serum cancer antigen 125 array for diagnosis of ovarian cancer in Chinese


1 Department of Gynaecology and Obstetrics, Chengdu Women's and Children's Central Hospital, Chengdu 610091, China
2 Department of Oncology, The People's Hospital of Pi County, Chengdu, 611730, China

Correspondence Address:
Guo-Jun Huang
Department of Oncology, The People's Hospital of Pi County, Chengdu, 611730
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.145884

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Objective: To further evaluation the diagnosis accuracy of serum cancer antigen 125 (CA125) in the diagnosis of ovarian cancer in Chinese patients. Materials and Methods: The PubMed, Wanfang and CNKI databases were electric searched and relevant diagnosis trials were reviewed and finally included in this meta-analysis. The diagnosis sensitivity, specificity, positive likely hood ratio (+LR), negative likely hood ratio (−LR), diagnostic odds ratio (DOR) and receiver operating characteristic curve were pooled by Meta DiSc 1.4 software. Results: Nineteen studies with a total of 2426 subjects were included in this meta-analysis. The pooled sensitivity, specificity, +LR, −LR and DOR were 0.75 (95% confidence interval = 0.73-0.78), 0.80 (0.77-0.82), 4.52 (3.27-6.26), 0.31 (0.28-0.35) and 15.76 (10.45-23.75) respectively. The area under the summary receiver operating characteristic curve was 0.84. Conclusion: Serum CA125 was potential biomarker for diagnosis of ovarian cancer with acceptable diagnosis value.


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