Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 7  |  Page : 206-209

Association between P-Glycoprotein expression and response to chemotherapy in patients with osteosarcoma: A systematic and meta-analysis


Department of Orthopedics, Orthopedics Hospital of Wuhan, Wuhan 430033, China

Correspondence Address:
Wu-Sheng Kan
Department of Orthopedics, Orthopedics Hospital of Wuhan, Wuhan 430033
China
Zhi-Gang Zhao
Department of Orthopedics, Orthopedics Hospital of Wuhan, Wuhan 430033
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.145874

Rights and Permissions

Objective: The aim was to investigate the association between p-glycoprotein (Pgp) expression and response to chemotherapy in patients with osteosarcoma. Materials and Methods: We searched and included the openly published articles evaluated the correlation between Pgp expression and response to chemotherapy. The odds ratio (OR) of response rate for Pgp positive group versus Pgp negative group was aggregated by random or fixed effect model. Results: Twelve studies were included in our meta-analysis. The mean Pgp positive rate was 0.39 ± 0.10 with its range of (0.14-0.53). The summary response rate was 0.46 ± 0.16 in Pgp positive and 0.57 ± 0.27 in the Pgp negative group, with no statistical difference between two groups (P > 0.05). The pooled OR of response rate for Pgp positive group versus Pgp negative group was 0.75 with its 95% confidence interval of 0.47-1.22, indicating there was no association between Pgp expression and response to chemotherapy in patients with osteosarcoma. Conclusion: The present evidence indicated that there was no association between p-glycoprotein expression and chemotherapy response in patients with osteosarcoma.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1437    
    Printed42    
    Emailed0    
    PDF Downloaded87    
    Comments [Add]    

Recommend this journal