Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 7  |  Page : 201-205

Quantitative assessment of the influence of glutathione S-transferase M1 null variant on ovarian cancer risk


1 Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2 Department of Gynecology, Tianjin Central Hospital of Gynecology Obstetrics, Nankai District, Tianjin, China
3 Department of Anorectal Surgery, Affiliated hospital to Shandong university of traditional Chinese Medicine, Jinan city, Shandong Province, 250011, China
4 Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, China

Correspondence Address:
Dr. Xipeng Zhang
Department of Colorectal Surgery, Tianjin Union Medicine Center (UMC), 190 Jieyuan Road, Hongqiao District, Tianjin 300121
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.145872

Rights and Permissions

Objective: Many studies have reported the role of glutathione S-transferase Mu 1 (GST M1) polymorphism with ovary cancer risk, but the results remained controversial. Materials and Methods: To derive a more precise estimation of the relationship, a meta-analysis was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between GSTM1 polymorphism and ovary cancer risk. A total of 11 studies including 2709 cases and 3599 controls were also involved in this meta-analysis. Results: When all the eligible studies were pooled into this meta-analysis, no significant association between ovary cancer risk and GSTM1 polymorphism was found (OR = 1.010, 95% CI = 0.911-1.121, P heterogeneity = 0.174, P = 0.848). Discussion: Our meta-analysis supports that the GSTM1 polymorphism is not contributed to the risk of ovary cancer from currently available evidence.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1264    
    Printed34    
    Emailed2    
    PDF Downloaded79    
    Comments [Add]    

Recommend this journal