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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 7  |  Page : 167-177

Identification of potential biomarkers for clear cell renal cell carcinoma based on microRNA-mRNA pathway relationships


Department of Blood Purification, General Hospital of Shenyang Military Area Command, Shenyang 110000, Liaoning, China

Correspondence Address:
Ning Cao
Department of Blood Purification, General Hospital of Shenyang Military Area Command, 83 Wenhua Road, Shenyang 110000, Liaoning
China
Xu Li
Department of Blood Purification, General Hospital of Shenyang Military Area Command, 83 Wenhua Road, Shenyang 110000, Liaoning
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.145856

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Background: MicroRNAs (miRNAs) play important roles in tumor genesis. miRNA dysregulation has been widely studied and demonstrated in clear cell renal cell carcinoma (ccRCC). Materials and Methods: We applied a newly proposed method for selecting miRNAs that discriminate between healthy controls and cancers. We initially extracted different miRNAs and mRNAs and then selected miRNA-mRNA dysregulation pairs. The pathways that involved mRNAs were acquired according to the functional enrichment. We integrated the miRNAs, mRNAs, and pathways and constructed the miRNA-mRNA pathway relationships based on the derived significant miRNAs. Results: We acquired 566 antiregulated miRNA-mRNA pairs including 56 miRNAs and 485 mRNAs. Three significant pathways related to ccRCC, namely, arginine and proline metabolism, aldosterone-regulated sodium reabsorption, and oxidative phosphorylation, were observed. Based on the miRNA-mRNA pathway relationships, five significant miRNAs were identified as potential biomarkers: hsa-miR-425, hsa-miR-136, hsa-miR-335, hsa-miR-340, and hsa-miR-320d. Conclusion: This integrative network approach revealed important miRNAs in the ccRCC that can identify specific disease biomarkers, which can be used as targets for cancer treatment.


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