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Year : 2014  |  Volume : 10  |  Issue : 7  |  Page : 102-107

Aurora-A kinase: Potential tumor marker of osteosarcoma


Department of Orthopedic Surgery, Tongji Hospital, Tongji University, Shanghai 200065, China

Correspondence Address:
Xiaozhong Zhu
Department of Orthopedic Surgery, Tongji Hospital, Tongji University, No. 389 Xincun Road, Shanghai 200065
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.145804

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Aurora kinase family is a group of serine/threonine protein kinase. It is the main regulator in mitosis, including centrosome regulation, spindle formation, and chromosome separation. Aurora-A is an oncogene that is highly expressed in various human tumors, including osteosarcoma. Its high expression level and malignance and tumor metastasis are correlated. Aurora-A is a potential tumor marker. The progress of Aurora-A kinase in tumor research is summarized in this article.


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