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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 5  |  Page : 46-51

Kanglaite injection combined with chemotherapy versus chemotherapy alone in the treatment of advanced non-small cell lung carcinoma


1 Department of Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, China
2 Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, China
3 Department of Oncology, Shandong University Affiliated Jinan Central Hospital, Jinan 250013, China
4 Department of Emergency, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, China
5 Department of Epidemiology, Xinxiang Medical University, Xinxiang 453100, China

Correspondence Address:
Xiaoge Kou
Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.139758

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Objective: To evaluate the clinical efficacy of Kanglaite (KLT) injection combined with chemotherapy versus chemotherapy alone in the treatment of advanced non-small cell lung carcinoma (NSCLC) by meta-analysis. Materials and Methods: Electronic search of PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases was conducted to select studies about KLT injection combined with chemotherapy versus chemotherapy alone in the treatment of advanced NSCLC. The pooled risk ratio (RR) and its 95% confidence interval (95% CI) for objective response rate (ORR), Karnofsky (KPS) score improvement and nausea and vomiting were calculated by Stata11.0 statistical software. Result: Finally, we included 34 clinical trials in this meta-analysis. The pooled results suggested that KLT injection combined with systematic chemotherapy can significantly increase the objective response rate (ORR) [RR = 1.35, 95% CI: 1.23-1.48, (Z = 6.43, P = 0.000)], the quality of patients' life (KSP improvement) [RR = 2.04, 95% CI: 1.79-2.33, (Z = 10.57, P = 0.000)] and decrease the risk ratio of gastrointestinal reaction [RR = 0.53, 95% CI: 0.42-0.66, (Z = 5.53, P = 0.000)] compared with chemotherapy alone. Conclusion: KLT injection combined with chemotherapy can improve the short-term efficacy, performance status and decrease the risk of gastrointestinal reaction compared with systematic chemotherapy alone.


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