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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 945-950

Primary extranodal non-Hodgkin's lymphoma of oral cavity - A single centre retrospective study


1 Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Banglore, Karnataka, India
2 Department of Pathology, Kidwai Memorial Institute of Oncology, Banglore, Karnataka, India

Correspondence Address:
Dr. Umesh Das
Room no. 102, PG Hostel, Kidwai Memorial Institute of Oncology, M.H. Mari Gowda Road, Banglore - 560 029, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.136024

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Background: Extra nodal involvements of non-Hodgkin's lymphomas (NHL) are not so uncommon, but the involvement of oral cavity by NHL is very rare. Materials and Methods: The present study involved retrospective analysis of patients from year 2001 to 2011, who presented with oral mass and on evaluation were diagnosed to have primary extranodal NHL of oral cavity at a tertiary cancer care centre in South India. Results: There were seven patients treated for primary NHL of oral cavity at our institute in last 10 years. The median age at presentation was 43.2 years (range 29-65 years). There were five males and two females. Oral tongue was the most common site (three patients) followed by alveolus (two patients). The other sites of involvement included gingivobuccal sulcus in one patient and hard palate in one patient. All patients were initially evaluated at oral oncology department for gradually increasing ulcerative mass in oral cavity. None of the patients had B symptoms. In our study, plasmablastic lymphoma was the most common type of NHL, followed by diffuse large B cell lymphoma (DLBCL) and peripheral T cell lymphoma, not otherwise specified (PTCL, NOS). Out of seven patients, two were HIV positive, both having plasmablastic lymphoma. Four out of the seven patients received a combination of chemotherapy and radiotherapy and three patients received only chemotherapy. Only three patients could complete the prescribed chemotherapy and radiotherapy schedule and were alive and diseases free with a median follow-up of 21 months. Conclusion: Involvement of oral cavity by lymphoma is rare. Plasmablastic lymphoma was the most common oral cavity NHL in our patients. Although number of cases in present study was less, our data suggests that oral NHL has aggressive course with less favorable outcome. Further large sample studies incorporating rituximab-based chemotherapy and more aggressive chemotherapy for plasmablastic lymphoma will be helpful for better understanding of treatment outcome.

Abstract in Chinese

口腔原发性结外非霍奇金淋巴瘤-单中心的回顾性研究 摘要 背景:非霍奇金淋巴瘤(NHL)节外的损害并不少见,但口腔的损害是非常罕见的。 材料与方法:本研究包括2001年到2011年的病例的回顾性分析,这些病人以口腔巨大肿块为表现,并在印度南部的一个三级癌症医疗中心诊断为口腔原发性结外淋巴瘤。 结果:过去的10年里,有7例口腔原发NHL在我院治疗。发病时的平均年龄为43.2岁(从29岁-65岁)。有5名男性和2名女性。舌是最常见的部位(3例),牙槽(2例)。其他部位的损害,包括龈颊沟(1例)和硬腭(1例)。所有患者最初都是在口腔肿瘤科被诊断的,主诉为逐步增大的口腔溃疡性肿块。没有病人有B症状。在我们的研究中,浆细胞淋巴瘤是NHL最常见的类型,其次是弥漫性大B细胞淋巴瘤(DLBCL)和非特指性外周T细胞淋巴瘤(PTCL,NOS)。在7例患者中,2例HIV阳性,均具有浆细胞性淋巴瘤。7例病人中4例接受放疗联合化疗,3例接受化疗。只有3例患者能完成规定的放疗和化疗的进度,直到中位随访21个月结束还无病生存。 结论:口腔损害淋巴瘤是罕见的。浆细胞淋巴瘤是最常见的口腔NHL。虽然本研究病例数较少,我们的数据表明,口腔NHL具有侵袭性,结果不容乐观。进一步的大样本的研究包括对浆细胞淋巴瘤的基于利妥昔单抗的化疗和更积极的化疗,将有助于更好地了解治疗效果。 关键词:结外,非霍奇金淋巴瘤,口腔



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