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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 922-926

Prognostic significance and predictive performance of volume-based parameters of F-18 FDG PET/CT in squamous cell head and neck cancers


1 Department of Nuclear Medicine, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
2 Department of Head and Neck Surgery, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey

Correspondence Address:
Sait Sager
Department of Nuclear Medicine, Istanbul University, Cerrahpasa Medical Faculty, Cerrahpasa, Fatih, Istanbul
Turkey
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Source of Support: We would like to thank the Scientific Research Projects Coordination Unit of Istanbul University, Conflict of Interest: None


DOI: 10.4103/0973-1482.137968

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Aim: It has been previously reported that metabolic tumor volume on positron emission tomography-computed tomography predicts disease recurrence and death in head-and-neck cancer. In this study, we assessed the prognostic value of metabolic tumor volume measured using F18-Fluorodeoxyglucose PET/CT in patients with head and neck squamous cell carcinoma. Materials and Methods: We analyzed the imaging findings of 74 patients (age 57 ± 16) retrospectively, with head and neck cancer who underwent PET/CT scan for staging and after treatment. Forty-tree patients had nasopharynx, 15 patients had hypopharynx, 9 patients had larynx, and 7 patients had oropharynx cancer. The MTVs of primary sites with or without lymph nodes were measured, and outcomes were assessed using the treatment response evaluation by the Response Evaluation Criteria in Solid Tumors and recurrence events during follow-up. Results: A total of 48 patients had complete response or no recurrence was detected as of in the last follow-up. Of the first PET/CT scan, the median primary tumor SUVmax was 18.8 and the median nodal SUVmax was 13.4. The median primary tumor MTV% 50s ranged from 11.12 cm 3 to 16.28 cm 3 , and the MTV after the therapy ranged from 1.18 cm 3 to 3.51 cm 3 . Conclusion: Metabolic tumor volume (MTV) represents tumor burden, which shows F18-Fluorodeoxyglucose uptake and has a potential value in predicting short-term outcome and disease-free survival in patients with head and neck cancer.

Abstract in Chinese

基于容积的 F-18 FDG PET/CT参数在头颈部鳞癌中的预后意义和疾病的预示 摘要 目的:先前已报道PET/CT代谢肿瘤体预示头颈部癌的复发、死亡。在这项研究中,我们对头颈部鳞癌患者行F-18 PET/CT检查,评估代谢肿瘤体积对头颈肿瘤预后的价值。 材料和方法:我们分析回顾了74例患者的影像学表现(57±16岁),这些头颈部癌患者分别在分期和治疗后进行了PET/CT检查。43例患者有鼻咽癌,15例下咽癌,9例喉癌,7例口咽癌。对原发灶包括或不包括淋巴结的代谢肿瘤体积(MTV)进行了测量,使用实体瘤疗效评价标准对结果进行治疗反应评估,随访复发事件。 结果:直到最后一次随访,共48例患者完全缓解或没有检测到复发。第一次PET / CT扫描中,平均原发肿瘤SUVmax为18.8,中位淋巴结SUVmax为13.4。中位原发肿瘤 MTV% 50s从11.12cm3到16.28cm3,而治疗后MTV的范围从1.18cm3到3.51cm3。 结论:代谢肿瘤体积(MTV)代表肿瘤的负担,这表明F18-脱氧葡萄糖摄取有潜在的预测头颈癌患者短期预后和无瘤生存的价值。 关键词:代谢肿瘤体积,最大标准摄取值,PET / CT



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