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Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 908-914

Oral squamous cell carcinoma in a South African sample: Race/ethnicity, age, gender, and degree of histopathological differentiation

1 Department of Periodontology and Oral Medicine, University of Limpopo, Medunsa Campus, Limpopo Province, South Africa
2 Department of Oral Pathology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa

Correspondence Address:
L Feller
Department of Periodontology and Oral Medicine, Box D26 School of Dentistry, Medunsa-0204
South Africa
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.138100

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Objectives: The purpose of this retrospective study was to investigate differences between black and white persons with oral squamous cell carcinoma (OSCC) with regard to age, gender, oral site affected, and histopathological degree of differentiation; and to compare these clinicopathological parameters between persons younger and older than 40 years in a South African population sample from the greater Johannesburg area. Material and Methods: The histopathological reports of 510 cases of OSCC during the period 1995-2002 were retrospectively evaluated, and the data regarding age, gender, ethnicity/race, oral site affected, and degree of histopathological differentiation were recorded and statistically analyzed for differences between black and white persons, and between persons younger and older than 40 years of age. Results: Statistically significantly, black persons were diagnosed with OSCC at a younger mean age (57 years) than white persons (61 years) (P = 0.0086). The difference between male: female (M: F) ratio in black (3.74:1) and white persons (1.96:1) was statistically significant (P = 0.0041). White persons had a significantly higher proportion of SCC of the lower lip than black persons (P < 0.0001). Conclusion: OSCC was diagnosed at a younger age in black than in white persons; the proportion of black males in the black population group was greater than that of white males in the white population group; and the proportion of SCC of the lips was higher in younger than in older persons.

Abstract in Chinese

南非的口腔鳞状细胞癌:种族、年龄、性别和组织学分化程度 摘要 目的:本研究旨在探讨黑人和白人之间的口腔鳞状细胞癌(OSCC)在年龄、性别、受影响口腔部位,组织病理学分化程度的差异,对南非大约翰内斯堡地区小于和大于40岁的人口样本进行临床病理参数的比较。 材料与方法:对1995-2002年期间510例口腔鳞癌病理报告进行回顾性评估,对黑人和白人之间,以及小于和大于40岁人群之间的关于年龄,性别,种族/民族,受影响口腔部位,与病理分化程度的数据进行记录和统计分析其差异。 结果:黑的人被诊断为口腔鳞状细胞癌的平均年龄较年轻(57岁),相比白种人(61岁)(P = 0.0086),有统计学意义。男性:女性(男:女)的差值比,黑人为(3.74:1),白人(1.96:1),有统计学意义(P = 0.0041)。白人下唇发生鳞癌的比例比黑人更明显(P<0.0001)。 结论:口腔鳞状细胞癌的诊断年龄黑人比白人小;黑人男性(发病)的比例高于白人男性;唇部鳞癌的比例年轻人高于年龄大的人。 关键词:年龄,病理学特征,性别,种族,鳞状细胞癌,南非

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