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Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 846-852

Cancer stem cells: An insight and future perspective


1 Department of Oral Medicine and Radiology, Adesh Institute of Dental Sciences and Research, Bathinda, Punjab, India
2 Department of Community Medicine, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India
3 Department of Periodontology, Institute of Dental Studies and Technologies, Kadrabad, Modi Nagar, Uttar Pradesh, India

Correspondence Address:
Sandeep Kaur
Department of Oral Medicine and Radiology, Adesh Institute of Dental Studies and Research, Barnala Road, Bathinda, Punjab - 151 109
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.139264

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The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated tissue clones whose continued propagation is vested in a biologically distinct subset of cells that are typically rare. Rare CSCs have been isolated from a number of human tumors, including hematopoietic, brain, colon, and breast cancer. With the growing evidence that CSCs exist in a wide array of tumors, it is becoming increasingly important to understand the molecular mechanisms that regulate self-renewal and differentiation because corruption of genes involved in these pathways likely participates in tumor growth. Understanding the biology of CSCs will contribute to the identification of molecular targets important for future therapies.

Abstract in Chinese

肿瘤干细胞研究与展望 摘要 癌症干细胞(CSC)的概念源于一个事实,癌症是失调的组织克隆,其持续发展归属于生物学的不寻常的细胞亚群,这类细胞亚群通常是罕见的。罕见的肿瘤干细胞已从许多人类肿瘤中分离出来,包括血液、脑、结肠、乳腺癌。随着越来越多的证据表明,干细胞广泛存在于肿瘤中,理解调节自我更新和分化的分子机制显得越来越重要,这是因为参与这些途径的基因变异可能参与了肿瘤生长。了解干细胞的生物学特性将有助于证明未来治疗方法中分子靶向的重要性。 关键词:肿瘤干细胞,增殖,自我更新失调,致瘤性,信号



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