Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 834-838

Cholelithiasis, cholecystectomy and risk of hepatocellular carcinoma: A meta-analysis


Department of General Surgery, Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province, China

Correspondence Address:
Prof. Yumin Li
Department of General Surgery, Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.135992

Rights and Permissions

Available evidence of the relationship between cholelithiasis, cholecystectomy, and risk of liver cancer and hence we conducted a meta-analysis to investigate the relationships. PubMed, EMBASE, and ISI Web of Knowledge were searched to identify all published cohort studies and case-control studies that evaluated the relationships of cholelithiasis, cholecystectomy and risk of liver cancer and single-cohort studies which evaluated the incidence of liver cancer among patients who understood cholecystectomy (up to February 2013). Comprehensive meta-analysis software was used for meta-analysis. A total of 11 observational studies (six cohort studies and five case-control studies) were included in this meta-analysis. The result from meta-analysis showed that cholecystectomy (risk ratio [RR]: 1.59, 95% confidence interval [CI]: 1.01-2.51, I2 = 72%) and cholecystolithiasis (RR: 5.40, 95% CI: 3.69-7.89, I2 = 93%) was associated with more liver cancer, especially for intrahepatic cholangiocarcinoma (ICC) (cholecystectomy: RR: 3.51, 95% CI: 1.84-6.71, I2 = 26%; cholecystolithiasis: RR: 11.06, 95% CI: 6.99-17.52, I2 = 0%). The pooled standardized incidence rates (SIR) of liver cancer in patients who understood cholecystectomy showed cholecystectomy might increase the incidence of liver cancer (SIR: 1.57, 95% CI: 1.13-2.20, I2 = 15%). Based on the results of the meta-analysis, cholecystectomy and cholecystolithiasis seemed to be involved in the development of liver cancer, especially for ICC. However, most available studies were case-control studies and short-term cohort studies, so the future studies should more long-term cohort studies should be well-conducted to evaluate the long-term relationship.

Abstract in Chinese

胆结石、胆囊切除术和肝细胞癌的风险:一项荟萃分析 摘要 现有的证据证实胆石症、胆囊切除术与肝癌的风险之间的关系,因此我们进行了一项荟萃分析研究。在PubMed,EMBASE,ISI Web of Knowledge中进行检索,找出所有发表关于胆石症、胆囊切除、肝癌的关系的队列研究和病例对照研究评价,和单队列研究评估了胆囊切除术患者的肝癌的发病率(至2013年2月)。综合分析软件进行Meta分析。共有11个观察性研究(6项队列研究和5个病例对照研究)进行Meta分析。从元分析结果表明,胆囊切除术(风险比[RR]:1.59,95%可信区间[CI]:1.01-2.51,I2 = 72%)和胆囊结石(RR :5.40,95% CI:3.69-7.89,I2 = 93%)与肝癌相关,特别是肝内胆管细胞癌(ICC)(胆囊切除术:RR:3.51,95%可信区间:1.84-6.71,I2 = 26%;胆囊结石:RR: 11.06,95% CI:6.99-17.52,I2 = 0)。汇集肝癌标准化发病率(SIR)接受胆囊切除术者可能会增加肝癌的发生率(SIR:1.57,95%可信区间:1.13-2.20,I2 = 15%)。基于Meta分析的结果,胆囊切除、胆囊结石似乎在肝癌发展过程中有关,尤其是肝内胆管细胞癌。但是多数病例对照研究是短期研究,因此,未来的研究应该更多地进行长期队列研究,并行长期关系的评估。 关键词:胆囊切除术,胆囊结石,肝肿瘤,Meta分析



[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2530    
    Printed72    
    Emailed0    
    PDF Downloaded194    
    Comments [Add]    

Recommend this journal