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REVIEW ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 805-810

Regulatory mechanisms and clinical perspectives of miR-34a in cancer


Department of Radiology, Children's Hospital of Soochow University, Suzhou, China

Correspondence Address:
Lei Li
Department of Radiology, Children's Hospital of Soochow University, 303 Jingde Lu, Suzhou 215000
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.146084

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MicroRNAs (miRNAs) are evolutionarily conserved, endogenous, noncoding RNA molecules of about 22-24 nucleotides in length that repress gene expression at the posttranscriptional level. MiR-34a plays an important role in the initiation, progression, and therapy of cancer. In addition, the miR-34a expression has also been identified as a diagnostic and prognostic cancer signature. This article introduces the roles of miR-34a in cancer development, metastasis as well as its mechanism of actions on target genes and the functional outcomes of its actions on radio-sensitivity. The paper ends with a brief perspective to the future of miR-34a.

Abstract in Chinese

miR-34a在肿瘤中的调控机制及临床意义 摘要 微核糖核酸(miRNAs)是进化上高度保守的内源性非编码RNA分子,约22的24个核苷酸长度,抑制转录后水平的基因表达。MiR-34a在肿瘤的发生、发展和治疗中起着重要的作用。此外,MiR-34a的表达也被确定为癌症诊断和预后的标志。本文介绍了miR-34a在癌症发展、转移的作用以及其对靶基因的作用机制及对放射敏感性的作用的功能性结果。文章最后简要地对miR-34a的未来发表了看法。 关键词:癌,临床应用,miR-34a



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