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Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 1101-1103

Sphenoidal esthesioneuroblastoma treated with sequential chemo radiotherapy: A case report and review of the literature

Department of Clinical Oncology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Omar Abdel-Rahman
Department to Clinical Oncology, Faculty of Medicine, Ain Shams University, Lotfy Elsayed Street, Cairo, Postal Code: 11665
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.146110

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Esthesioneuroblastoma (ENB)-also known as olfactory neuroblastoma-originates primarily from the olfactory epithelium in the roof of the nasal cavity. We present here the 7 th reported case of ENB arising from the sphenoidal sinus. We undertook a review of the case notes from the time of initial presentation and literature review of this topic. A 55-year-old male presented with a 3-year history of unilateral progressive nasal obstruction, epistaxis, difficult nasal-breathing, facial pain, frontal headache and blood-tinged discharge. Nasal examination revealed a glistening mass in right nasal cavity. Endoscopy-assisted transnasal excision was performed. Histologically, tumor was identified as small round cell tumor and confirmed by immunohistochemistry to be olfactory neuroblastoma (negative leucocyte common antigen, positive neurone specific enolase). Sphenoidal ENB is rare in the literature, and this presentation is the 7 th reported case; in addition, surgical treatment is very challenging, and non-surgical treatment is used most commonly.

Abstract in Chinese

序贯放化疗治疗蝶窦嗅神经母细胞瘤:1例报告及文献复习 摘要 嗅神经母细胞瘤(ENB)也被称为嗅成神经母细胞瘤,主要来源于在鼻腔顶的嗅上皮。在此我们报道第7例ENB,源于蝶窦,以及有关的文献回顾。一位55岁的男性,有3年病史的单侧渐进性鼻塞,鼻出血,鼻呼吸困难,面部疼痛,头痛和血涕。鼻腔检查显示右鼻腔肿块。内镜下经鼻切除。组织学上,肿瘤被确定为小圆细胞肿瘤,经免疫组化确诊是嗅神经母细胞瘤(白细胞共同抗原阴性,神经元特异性烯醇化酶阳性)。蝶ENB在文献中是罕见的,这例报道是第7例;此外,手术治疗是非常具有挑战性的,非手术治疗也是最很常用的。 关键词:嗅神经母细胞瘤,化疗,放疗,鼻窦,蝶窦肿瘤

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