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Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 1076-1081

Comparison of clinicopathological parameters with FoxM1 expression in renal cell carcinoma

1 Department of Pathology, Faculty of Medicine, Harran University, Sanliurfa, Turkey
2 Department of Pathology, Sanliurfa Balikligol State Hospital, Sanliurfa, Turkey
3 Department of Urology, Faculty of Medicine, Harran University, Turkey
4 Department of Pathology, Faculty of Medicine, Kocatepe University, Afyonkarahisar, Turkey

Correspondence Address:
Sezen Kocarslan
Department of Pathology, Faculty of Medicine, Harran University, Yenisehir campus, Sanliurfa
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.137988

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Aim: To investigate the relationships between expression of forkhead box M1 (FoxM1) and clinicopathologic parameters and Ki-67 expression in patients with renal cell carcinoma (RCC). Materials and Methods: A total of 67 cases of RCC including 47 cases of clear cell RCC (ccRCC), five cases of papillary RCC (pRCC), eight cases of chromophobe RCC (chRCC), four cases of unclassified (with sarcomatoid pattern) RCC (sRCC), and three cases of multilocular RCC (mRCC) were included to this study. The expression of FoxM1 protein was assessed in 67 samples of RCC using immunohistochemical methods and the relationship between the expression levels of FoxM1 with clinicopathological characteristics and Ki-67 expression of RCC patients. For statistical analysis, the cases were grouped into the ccRCC and non-ccRCC group. Results: Immunohistochemistry analyses showed that FoxM1 protein expression in 47 ccRCC samples was significantly correlated with tumor size, stage, nuclear grade, capsule invasion, perinephric fat invasion, and Ki-67 expression (P < 0.05 for all); whereas, no correlations were found in patients' age, gender, and lymph node metastasis (P > 0.05 for all). In 20 non-ccRCC; overexpression of FoxM1 was strongly associated with tumor size (P < 0.05). There was no relationship between FoxM1 expression with other clinicopathological parameters and Ki-67 expression in non-ccRCC (P > 0.05 for all). Conclusion: This study showed that FoxM1 have a progressive oncogenic role in ccRRC. Our results suggested that higher expression of FoxM1 in tumor tissues predicts a locally aggressive behavior and poor outcome of patients with ccRCC, but not in patient with non-ccRCC.

Abstract in Chinese

肾细胞癌的临床病理参数与FOXM1表达的比较 摘要 目的:探讨肾细胞癌(RCC)患者FOXM1表达、临床病理参数和Ki-67的表达之间的关系。 材料和方法:共67例肾细胞癌(RCC),包括透明细胞癌(ccRCC)47例,乳头状癌(pRCC)5例,嫌色细胞癌(chRCC)8例,未分类的4例(伴肉瘤样型)(sRCC),和多房性肾癌(mRCC)3例。采用免疫组化方法测定FOXM1蛋白在67例RCC的表达,评价FOXM1表达与临床病理参数、Ki -67表达水平之间的关系。为了统计分析,病例分为透明细胞癌组和非透明细胞癌组。 结果:免疫组化分析表明47例ccRCC样本FOXM1蛋白表达与肾透明细胞癌肿瘤大小,阶段,核级,包膜浸润,肾周脂肪浸润,及Ki -67的表达显著相关(P<0.05);发现与患者年龄、性别和淋巴结转移没有相关(P > 0.05)。在20例非透明细胞癌中, FOXM1过度表达与肿瘤大小密切相关(P<0.05),而与其他临床病理参数及Ki- 67的表达没有相关性(P>0.05)。 结论:本研究表明FOXM1在ccRRC中有渐进的致癌作用。我们的研究结果表明,透明细胞癌患者肿瘤组织中FOXM1的高表达预示局部侵袭性行为,预后差,但在非透明细胞癌病人中不是这样。 关键词:临床病理参数,FOXM1,Ki-67,免疫组织化学,肾细胞癌

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